Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 4/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4396585 | 0.91 | LMNA (0.40) | HTR1APARP1LMNAADRB3HTR7 | |
| SCHEMBL4409085 | 0.88 | LMNA (0.40) | HTR1APARP1LMNAADRB3HTR7 | |
| SCHEMBL4402091 | 0.88 | LMNA (0.42) | HTR1AHTR4PARP1LMNAADRB3 | |
| SCHEMBL4551166 | 0.88 | LMNA (0.42) | HTR1AHTR4PARP1LMNAADRB3 | |
| SCHEMBL4405571 | 0.88 | KDM4E (0.39) | HTR1APARP1LMNAADRB3HTR7 | |
| SCHEMBL6962267 | 0.88 | HTR1A (0.43) | HTR1AHTR4PARP1HTR7 | |
| SCHEMBL914822 | 0.88 | HTR1A (0.43) | HTR1AHTR4PARP1HTR7 | |
| SCHEMBL914697 | 0.88 | HTR1A (0.43) | HTR1AHTR4PARP1HTR7 | |
| SCHEMBL4405829 | 0.87 | PARP1 (0.37) | HTR1APARP1LMNAADRB3HTR7 | |
| SCHEMBL4406787 | 0.87 | PARP1 (0.37) | HTR1APARP1LMNAADRB3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |