SCHEMBL440285

SCHEMBL440285

COC(C)COC(=O)C=CC#N

nearest known ligand 0.40

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.40
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4890618 0.94 TSHR (0.36) TSHRALDH1A1HPGD
SCHEMBL168359 0.87 TSHR (0.53) TSHRALDH1A1HPGDTDP1
SCHEMBL4885631 0.86 TSHR (0.33) TSHR
SCHEMBL2046400 0.85 TSHR (0.48) TSHRALDH1A1HPGDTDP1
SCHEMBL35691 0.83 LMNA (0.38) TDP1
SCHEMBL4891419 0.82 TSHR (0.35) TSHRALDH1A1HPGD
SCHEMBL4891948 0.80 TSHR (0.33) TSHR
SCHEMBL19699816 0.79 HCAR2 (0.52) TSHRALDH1A1HPGDTDP1
SCHEMBL19699814 0.79 HCAR2 (0.52) TSHRALDH1A1HPGDTDP1
SCHEMBL10530524 0.78 TSHR (0.45) TSHRALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 153 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023194367-A1 TWO-PART CURABLE COMPOSITION BOSTIK SA (FR) 2023-10-12 WO claimed
EP-4257648-A1 TWO-PART CURABLE COMPOSITION Bostik SA (FR) 2023-10-11 EP claimed
US-20220185929-A1 TWO-PART CURABLE COMPOSITION BOSTIK SA (FR) 2022-06-16 US claimed
EP-3941987-A1 TWO-PART CURABLE COMPOSITION Bostik SA (FR) 2022-01-26 EP claimed
WO-2020187963-A1 TWO-PART CURABLE COMPOSITION BOSTIK SA (FR) 2020-09-24 WO claimed
EP-3191561-B1 FAST AND ELASTIC ADHESIVE AFINITICA TECH S L (ES) 2020-05-06 EP claimed
US-10626299-B2 Fast and elastic adhesive AFINITICA TECHNOLOGIES, S.L. (ES) 2020-04-21 US claimed
EP-2995664-B1 Fast and universal adhesive AFINITICA TECH S L (ES) 2019-08-28 EP claimed
US-20170260422-A1 FAST AND ELASTIC ADHESIVE AFINITICA TECHNOLOGIES, S. L. (ES) 2017-09-14 US claimed
EP-3191561-A1 FAST AND ELASTIC ADHESIVE Afinitica Technologies, S. L. (ES) 2017-07-19 EP claimed
WO-2016038514-A1 FAST AND ELASTIC ADHESIVE AFINITICA TECHNOLOGIES, S. L. (ES) 2016-03-17 WO claimed
EP-2995663-A1 Fast and elastic adhesive Afinitica Technologies, S. L. (ES) 2016-03-16 EP claimed
EP-2995664-A1 Fast and universal adhesive Afinitica Technologies, S. L. (ES) 2016-03-16 EP claimed
US-20100112036-A1 Cyanoacrylate-based liquid microbial sealant drape ADHEZION BIOMEDICAL, LLC. (US) 2010-05-06 US claimed
WO-2010051445-A2 CYANOACRYLATE-BASED LIQUID MICROBIAL SEALANT DRAPE ADHEZION BIOMEDICAL, LLC. (US) 2010-05-06 WO claimed
US-20070248560-A1 Cosmetic product comprising at least one cyanoacrylate monomer and at least one non-ionic polyurethane L'OREAL S.A. (FR) 2007-10-25 US claimed
US-5665107-A Surface opening adhesive sealer HEMODYNAMICS, INC. (US) 1997-09-09 US claimed
US-5653730-A Surface opening adhesive sealer HEMODYNAMICS, INC. (US) 1997-08-05 US claimed
US-5529577-A Surface opening adhesive sealer HEMODYNAMICS, INC. (US) 1996-06-25 US claimed
US-5383899-A Method of using a surface opening adhesive sealer HEMODYNAMICS, INC. 1995-01-24 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070248560-A1 Cosmetic product comprising at least one cyanoacrylate monomer and at least one non-ionic polyurethane KRT18, CUTA, DSG1 TSHR 4475/4885ALDH1A1 307/4885HPGD 467/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.