Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 10/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 10/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 10/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4402416 | 0.86 | LIPE (0.50) | LIPENAMPTCYP3A4CYP2C9TLR9 | |
| SCHEMBL16994796 | 0.84 | TLR9 (0.51) | LIPETLR9TLR8TLR7TSHR | |
| SCHEMBL3527556 | 0.83 | TLR7 (0.47) | NAMPTCYP3A4CYP2C9TLR9TLR8 | |
| SCHEMBL4404007 | 0.83 | MEN1 (0.54) | LIPENAMPTTSHRTP53MEN1 | |
| SCHEMBL4403149 | 0.82 | NAMPT (0.47) | LIPENAMPTCYP3A4CYP2C9TLR9 | |
| SCHEMBL4402422 | 0.81 | LIPE (0.47) | LIPENAMPTCYP3A4CYP2C9TLR9 | |
| SCHEMBL4402414 | 0.81 | QDPR (0.59) | LIPETP53MEN1KMT2ALMNA | |
| SCHEMBL12928763 | 0.81 | TRPC6 (0.43) | TLR9TLR8TLR7TSHR | |
| SCHEMBL11916169 | 0.79 | MAPT (0.54) | TSHRTP53MEN1KMT2ALMNA | |
| SCHEMBL3534489 | 0.78 | NAMPT (0.53) | NAMPTCYP3A4CYP2C9TLR9TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150353495-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | ALEXION PHARMACEUTICALS, INC. | 2015-12-10 | — | — | US | disclosed |
| US-9102625-B2 | Nicotinamides as JAK kinase modulators | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-08-11 | — | — | US | disclosed |
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353495-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | JAK2, JAK1, NADK | LIPE 2549/4885NAMPT 6/4885CYP3A4 639/4885 |
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | JAK2, JAK1, NADK | LIPE 2549/4885NAMPT 6/4885CYP3A4 639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.