Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 14/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4410325 | 0.92 | DGAT1 (0.50) | DGAT1MAPTAURKARAB9A | |
| SCHEMBL4403262 | 0.89 | DGAT1 (0.55) | DGAT1KLKB1NPC1RAB9A | |
| SCHEMBL4403257 | 0.84 | DGAT1 (0.63) | DGAT1 | |
| SCHEMBL4291947 | 0.81 | DGAT1 (0.74) | DGAT1 | |
| SCHEMBL4410327 | 0.81 | DGAT1 (0.57) | DGAT1 | |
| SCHEMBL4410322 | 0.76 | DGAT1 (0.65) | DGAT1 | |
| SCHEMBL4296532 | 0.73 | DGAT1 (0.76) | DGAT1 | |
| SCHEMBL4289819 | 0.70 | DGAT1 (0.75) | DGAT1 | |
| SCHEMBL4289322 | 0.69 | DGAT1 (0.73) | DGAT1 | |
| SCHEMBL4403265 | 0.69 | DGAT1 (0.84) | DGAT1TP53NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044055-A2 | AMIDE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008011131-A2 | AMIDE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-01-24 | — | — | WO | disclosed |