Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 15/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4410327 | 0.92 | DGAT1 (0.57) | DGAT1 | |
| SCHEMBL4403258 | 0.89 | DGAT1 (0.49) | DGAT1NPC1RAB9AKLKB1 | |
| SCHEMBL4291947 | 0.86 | DGAT1 (0.74) | DGAT1 | |
| SCHEMBL4403257 | 0.81 | DGAT1 (0.63) | DGAT1 | |
| SCHEMBL4410325 | 0.81 | DGAT1 (0.50) | DGAT1RAB9A | |
| SCHEMBL4296532 | 0.78 | DGAT1 (0.76) | DGAT1 | |
| SCHEMBL4289819 | 0.76 | DGAT1 (0.75) | DGAT1 | |
| SCHEMBL4289322 | 0.75 | DGAT1 (0.73) | DGAT1 | |
| SCHEMBL4291772 | 0.74 | DGAT1 (0.87) | DGAT1 | |
| SCHEMBL4410322 | 0.73 | DGAT1 (0.65) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044055-A2 | AMIDE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008011131-A2 | AMIDE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-01-24 | — | — | WO | disclosed |