Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364227 | 0.92 | KDM4E (0.49) | KDM4EMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL363607 | 0.82 | ADORA3 (0.43) | KDM4EMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL295426 | 0.81 | MAPT (0.48) | KDM4EMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL8268871 | 0.80 | MAPT (0.47) | KDM4EMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL7273936 | 0.77 | SMN1; SMN2 (0.60) | KDM4EMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL4403200 | 0.76 | MAPT (0.49) | KDM4EMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL7267948 | 0.75 | KDM4E (0.54) | KDM4EMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL3318169 | 0.73 | KDM4E (0.77) | KDM4EMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL2703349 | 0.72 | KDM4E (0.45) | KDM4EMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL2704427 | 0.71 | PLA2G2A (0.44) | KDM4EMAPTSMN1; SMN2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888589-B1 | PYRROLOPYRIDINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS | BRISTOL MYERS SQUIBB CO (US) | 2012-05-09 | — | — | EP | disclosed |