Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7267861 | 0.83 | ALDH1A1 (0.46) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5314404 | 0.76 | SMN1; SMN2 (0.51) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL364227 | 0.75 | KDM4E (0.49) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4403279 | 0.75 | KDM4E (0.49) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7273936 | 0.74 | SMN1; SMN2 (0.60) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL18157027 | 0.74 | ALDH1A1 (0.50) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8268871 | 0.73 | MAPT (0.47) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL16851056 | 0.73 | ALDH1A1 (0.67) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL14719891 | 0.72 | ADORA3 (0.43) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL295426 | 0.72 | MAPT (0.48) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282904-B1 | 2-THIOMETHYL-SUBSTITUTED-PYRIDINES, A METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-08-26 | — | — | EP | disclosed |
| US-4918087-A | 2-thiomethyl-substituted-pyridine and -3,5-dicarboxylates having anti-hypertensive activity | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1990-04-17 | — | — | US | disclosed |
| EP-0282904-A2 | 2-Thiomethyl-substituted-pyridines, a method for their preparation and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1988-09-21 | — | — | EP | disclosed |