Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.46 |
| ▸ | CHRNA10 | Q9GZZ6 | 6/20 | 0.46 |
| ▸ | CHRNA9 | Q9UGM1 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CHKA | P35790 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4398933 | 0.93 | HTT (0.56) | HTTCHRNA7CHRNA10CHRNA9MEN1 | |
| SCHEMBL5292316 | 0.86 | KDM4E (0.53) | HTTCHRNA7CHRNA10CHRNA9MEN1 | |
| SCHEMBL4402115 | 0.84 | BCHE (0.50) | CHRNA7CHRNA10CHRNA9BCHEACHE | |
| SCHEMBL4403361 | 0.83 | CHRNA7 (0.41) | CHRNA7CHRNA10CHRNA9MAPTRAD52 | |
| SCHEMBL12638099 | 0.82 | HTT (0.62) | HTTCHRNA7CHRNA10CHRNA9MEN1 | |
| SCHEMBL4407138 | 0.82 | KDM4E (0.53) | CHRNA7CHRNA10CHRNA9MAPTRAD52 | |
| SCHEMBL4404627 | 0.82 | CHRNA7 (0.71) | CHRNA7CHRNA10CHRNA9MAPTRAD52 | |
| SCHEMBL4400715 | 0.80 | CHRNA7 (0.68) | HTTCHRNA7CHRNA10CHRNA9MEN1 | |
| SCHEMBL13334058 | 0.79 | HTT (0.58) | HTTCHRNA7CHRNA10CHRNA9CHKA | |
| SCHEMBL4403750 | 0.79 | TAAR1 (0.41) | CHRNA7CHRNA10CHRNA9KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178678-B2 | Bis-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2012-05-15 | — | — | US | disclosed |
| US-20100069432-A1 | Bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069432-A1 | Bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | CHRNA2, CHRNA5, CHRNA4 | HTT 603/4885CHRNA7 7/4885CHRNA10 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.