Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | ACACA | Q13085 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.40 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.40 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10282869 | 0.88 | ACACB (0.43) | ACACBACACAKIF11LRRK2MEN1 | |
| SCHEMBL1758985 | 0.86 | MAP2K4 (0.47) | ACACBACACANTRK1KMT2AMAPK1 | |
| SCHEMBL4403097 | 0.84 | ACACB (0.45) | ACACBACACALRRK2NTRK1MAPK1 | |
| SCHEMBL1759274 | 0.84 | KDM4E (0.47) | ACACBACACAKIF11NTRK1MEN1 | |
| SCHEMBL18555394 | 0.81 | HCRTR1 (0.53) | MEN1KMT2AMAPK1JAK2 | |
| SCHEMBL4404641 | 0.78 | JAK2 (0.58) | KIF11HTR1AHTR1DHTR1BJAK2 | |
| SCHEMBL16308650 | 0.78 | KIF11 (0.50) | KIF11MAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL16125483 | 0.76 | KIF11 (0.45) | KIF11MAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL15479089 | 0.76 | KIF11 (0.45) | KIF11MAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL4407745 | 0.76 | PRKAB2 (0.47) | KIF11MAPK1MAP2K4MAPKAPK3MAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012056372-A1 | N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2012-05-03 | — | — | WO | disclosed |