Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | KLK1 | P06870 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727183 | 0.82 | PROKR1 (0.38) | PROKR1 | |
| SCHEMBL24473725 | 0.76 | KDM5B (0.50) | KDM4EMAPT | |
| SCHEMBL14534850 | 0.76 | CRHR1 (0.43) | GBA1KMT2ASMN1; SMN2L3MBTL1KLKB1 | |
| SCHEMBL3276708 | 0.75 | CRHR1 (0.38) | KMT2AKDM4ELMNAMAPT | |
| SCHEMBL2996732 | 0.75 | MEN1 (0.48) | KMT2AKLKB1KLK1CDK1MTOR | |
| SCHEMBL13702295 | 0.74 | KDM5A (0.49) | SMN1; SMN2L3MBTL1KLKB1KLK1MAPK14 | |
| SCHEMBL1179121 | 0.73 | UHRF1 (0.48) | KMT2APROKR1KDM4E | |
| SCHEMBL13805996 | 0.72 | UHRF1 (0.46) | GBA1KMT2ASMN1; SMN2L3MBTL1CDK1 | |
| SCHEMBL13701783 | 0.72 | LMNA (0.45) | SMN1; SMN2POLBLMNANPC1MAPT | |
| SCHEMBL14508048 | 0.72 | FDPS (0.51) | KMT2ACYP1A2LMNACYP3A4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959951-B1 | HETEROARYL SUBSTITUTED PIPERIDINE DERIVATIVES AS L-CPT1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-12-23 | — | — | EP | disclosed |