Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 10/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL476762 | 0.75 | NR3C1 (0.67) | NR3C1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL4390639 | 0.75 | NR3C1 (0.50) | NR3C1CCR1CYP17A1CYP1A2 | |
| SCHEMBL12663246 | 0.74 | NR3C1 (0.54) | NR3C1CCR1NPC1RAB9AKDM4E | |
| SCHEMBL4390636 | 0.73 | NR3C1 (0.53) | NR3C1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL4400812 | 0.73 | NR3C1 (0.47) | NR3C1CCR1CYP17A1CYP1A2CYP3A4 | |
| SCHEMBL4396953 | 0.72 | NR3C1 (0.49) | NR3C1 | |
| SCHEMBL476811 | 0.68 | NR3C1 (0.69) | NR3C1 | |
| SCHEMBL476766 | 0.67 | NR3C1 (0.66) | NR3C1CYP3A4CYP2C9 | |
| SCHEMBL4400814 | 0.67 | NR3C1 (0.54) | NR3C1CYP3A4CYP2C9 | |
| SCHEMBL476867 | 0.67 | NR3C1 (0.69) | NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081910-A1 | NOVEL COMPOUNDS | Glaxo Group Limited (GB) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008043789-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-04-17 | — | — | WO | disclosed |