Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trimethylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 11/20 | 0.55 |
| ▸ | BCHE | P06276 | 9/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimethylammonium SCHEMBL4404158 | 0.78 | ACHE (0.56) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL11663910 | 0.77 | ACHE (0.84) | ACHEBCHELMNAMEN1KMT2A | |
| 3-Chlorophenyl Dimethylcarbamate SCHEMBL27758556 | 0.73 | ACHE (0.61) | ACHEBCHELMNAMEN1KMT2A | |
| Trimethylammonium SCHEMBL11599930 | 0.72 | NCEH1 (0.66) | ACHEBCHELMNAMEN1KMT2A | |
| M-Tolyl Dimethylcarbamate SCHEMBL8926857 | 0.72 | LMNA (0.65) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL2028206 | 0.71 | ACHE (0.89) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL9987576 | 0.71 | ACHE (0.86) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL41903 | 0.71 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| SCHEMBL16546689 | 0.71 | ACHE (0.58) | ACHEBCHELMNAMEN1KMT2A | |
| SCHEMBL29108030 | 0.70 | RAB9A (0.61) | ACHEBCHELMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4230202-A1 | BOWEL CARE USING IONTOPHORESIS | The United States Government Represented by the Department of Veterans Affairs (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-3413888-B1 | BOWEL CARE USING IONTOPHORESIS | US GOV VETERANS AFFAIRS (US) | 2023-05-10 | — | — | EP | disclosed |
| US-20190029989-A1 | BOWEL CARE USING IONTOPHORESIS | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2019-01-31 | — | — | US | disclosed |
| EP-3413888-A2 | BOWEL CARE USING IONTOPHORESIS | United States Government as Represented by The Department of Veterans Affairs (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139794-A2 | BOWEL CARE USING IONTOPHORESIS | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (US) | 2017-08-17 | — | — | WO | disclosed |
| US-7635709-B2 | Synergistic mixture of acetylcholinesterase inhibitor and anticholinergic agent; side effect reduction | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (US) | 2009-12-22 | — | — | US | disclosed |
| US-20040082644-A1 | Compositions and methods for bowel care in individuals with chronic intestinal pseudo-obstruction | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, DBA, THE DEPARTMENT OF VETERANS AFFAIRS | 2004-04-29 | — | — | US | disclosed |