Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
| ▸ | CHRNA10 | Q9GZZ6 | 2/20 | 0.43 |
| ▸ | CHRNA9 | Q9UGM1 | 2/20 | 0.43 |
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11580547 | 0.91 | PABPC1 (0.51) | LMNAL3MBTL1KDM4EALDH1A1GGPS1 | |
| SCHEMBL13361694 | 0.90 | LMNA (0.55) | LMNAKDM4EAPAF1ALDH1A1POLB | |
| SCHEMBL4400586 | 0.87 | KDM4E (0.59) | LMNAKDM4EAPAF1ALDH1A1POLB | |
| SCHEMBL4401584 | 0.85 | CHRNA7 (0.63) | LMNAL3MBTL1KDM4EAPAF1ALDH1A1 | |
| SCHEMBL6114658 | 0.85 | PABPC1 (0.50) | LMNAL3MBTL1KDM4EAPAF1ALDH1A1 | |
| SCHEMBL5295991 | 0.82 | CHRNA7 (0.50) | LMNAKDM4EAPAF1ALDH1A1POLB | |
| SCHEMBL13334363 | 0.81 | LMNA (0.64) | LMNAKDM4EAPAF1ALDH1A1POLB | |
| SCHEMBL8739576 | 0.81 | KDM4E (0.53) | LMNAKDM4EAPAF1ALDH1A1POLB | |
| SCHEMBL16673982 | 0.81 | KDM4E (0.48) | LMNAL3MBTL1KDM4EAPAF1ALDH1A1 | |
| Bromide SCHEMBL3312746 | 0.80 | LMNA (0.62) | LMNAKDM4EAPAF1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178678-B2 | Bis-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2012-05-15 | — | — | US | disclosed |
| US-20100069432-A1 | Bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069432-A1 | Bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | CHRNA2, CHRNA5, CHRNA4 | LMNA 3886/4885L3MBTL1 3428/4885KDM4E 1712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.