Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 3/20 | 0.57 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 7/20 | 0.48 |
| ▸ | DRD2 | P14416 | 6/20 | 0.48 |
| ▸ | HTR2A | P28223 | 6/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.44 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5728887 | 0.90 | AHR (0.54) | AHRMAOBHTR1ADRD2HTR2A | |
| SCHEMBL8670836 | 0.90 | AHR (0.59) | AHRMAOBHTR1ADRD2HTR2A | |
| SCHEMBL4889909 | 0.89 | AHR (0.53) | AHRMAOBHTR1ADRD2HTR2A | |
| SCHEMBL24570672 | 0.86 | AHR (0.61) | AHRMAOBHTR1ADRD2HTR2A | |
| SCHEMBL5466359 | 0.85 | MAOA (0.50) | MAOBHTR1ADRD2HTR2APDE3B | |
| SCHEMBL7349900 | 0.83 | AHR (0.53) | AHRMAOBHTR1ADRD2HTR2A | |
| SCHEMBL260866 | 0.83 | AHR (0.53) | AHRMAOBHTR1ADRD2HTR2A | |
| SCHEMBL15941764 | 0.83 | SMYD3 (0.55) | AHRMAOBHTR1ADRD2HTR2A | |
| SCHEMBL5766779 | 0.83 | MAPT (0.50) | AHRMAOBHTR1ADRD2HTR2A | |
| SCHEMBL4551283 | 0.81 | SMYD3 (0.50) | AHRMAOBHTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 142 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476162-B1 | CONTROLLED SYNTHESIS OF ZIPRASIDONE | PFIZER PROD INC (US) | 2007-04-18 | — | — | EP | claimed |
| CN-1635892-A | Controlled synthesis of ziprasidone and compositions thereof | PFIZER (US) | 2005-07-06 | — | — | CN | claimed |
| EP-1476162-A1 | CONTROLLED SYNTHESIS OF ZIPRASIDONE AND COMPOSITIONS THEREOF | Pfizer Products Inc. (US) | 2004-11-17 | — | — | EP | claimed |
| US-20040048876-A1 | Ziprasidone composition and synthetic controls | PFIZER INC. | 2004-03-11 | — | — | US | claimed |
| WO-2003070246-A1 | CONTROLLED SYNTHESIS OF ZIPRASIDONE AND COMPOSITIONS THEREOF | PFIZER PRODUCTS INC. (US) | 2003-08-28 | — | — | WO | claimed |
| EP-3115361-B1 | HETEROCYCLIC COMPOUNDS, AND PREPARATION METHOD AND USE THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2019-10-23 | — | — | EP | disclosed |
| US-10174011-B2 | Heterocyclic compounds, process for preparation of the same and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2019-01-08 | — | — | US | disclosed |
| US-20170158680-A1 | HETEROCYCLIC COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-06-08 | — | — | US | disclosed |
| US-20170158680-A1 | HETEROCYCLIC COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-06-08 | — | — | US | disclosed |
| EP-3115361-A1 | HETEROCYCLIC COMPOUNDS, AND PREPARATION METHOD AND USE THEREOF | Shanghai Institute Of Materia Medica Chinese Academy of Sciences (CN) | 2017-01-11 | — | — | EP | disclosed |
| WO-2015131856-A1 | HETEROCYCLIC COMPOUNDS, AND PREPARATION METHOD AND USE THEREOF | 中国科学院上海药物研究所 | 2015-09-11 | — | — | WO | disclosed |
| CN-104892589-A | Heterocyclic compound, preparation method therefor and use thereof | SHANGHAI INST MATERIA MEDICA | 2015-09-09 | — | — | CN | disclosed |
| US-5147881-A | 4-(1,2-BENZISOXAZOLYL)PIPERIDINE ANTIPSYCHOTIC AGENTS | PFIZER INC (US) | 1992-09-15 | — | — | US | disclosed |
| WO-1992008718-A1 | 4-(1,2-BENZISOXAZOLYL)PIPERIDINE ANTIPSYCHOTIC AGENTS | PFIZER INC. (US) | 1992-05-29 | — | — | WO | disclosed |
| EP-0281309-B1 | PIPERAZINYL-HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 1991-12-27 | — | — | EP | disclosed |
| WO-1990006303-A1 | ARYLPIPERIDINE DERIVATIVES | PFIZER INC. (US) | 1990-06-14 | — | — | WO | disclosed |
| EP-0372776-A2 | Arylpiperidine derivatives | PFIZER INC. (US) | 1990-06-13 | — | — | EP | disclosed |
| US-4883795-A | Piperazinyl-heterocyclic compounds | PFIZER INC. (US) | 1989-11-28 | — | — | US | disclosed |
| US-4831031-A | Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity | PFIZER INC. (US) | 1989-05-16 | — | — | US | disclosed |
| EP-0281309-A1 | Piperazinyl-heterocyclic compounds | PFIZER INC. (US) | 1988-09-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040048876-A1 | Ziprasidone composition and synthetic controls | SLC39A3, HAMP, NISCH | AHR 1643/4885MAOB 789/4885HTR1A 138/4885 |
| US-10174011-B2 | Heterocyclic compounds, process for preparation of the same and use thereof | CYP11B2, CYP11B1, ADCYAP1R1 | AHR 337/4885MAOB 97/4885HTR1A 1013/4885 |
| US-20170158680-A1 | HETEROCYCLIC COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF | CYP11B2, CYP11B1, ADCYAP1R1 | AHR 337/4885MAOB 97/4885HTR1A 1013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.