Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PDE9A | O76083 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 9/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 9/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.42 |
| ▸ | CDK2 | P24941 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44521 | 0.87 | RAB9A (0.45) | PDE5ARAB9AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL43869 | 0.77 | PDE5A (0.52) | PDE5AKDM4ELMNAPDE9APDE1A | |
| SCHEMBL38289 | 0.77 | PDE5A (0.63) | PDE5ARAB9AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL38312 | 0.76 | PDE5A (0.70) | PDE5ARAB9AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL37798 | 0.76 | PDE5A (1.00) | PDE5ARAB9AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL37584 | 0.75 | PDE5A (0.66) | PDE5ARAB9AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL37864 | 0.75 | PDE5A (0.82) | PDE5ARAB9AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL38275 | 0.75 | PDE5A (0.69) | PDE5ARAB9AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL37626 | 0.74 | PDE5A (0.80) | PDE5ARAB9AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL46289 | 0.72 | PDE5A (0.76) | PDE5ARAB9AKDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |