Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.76 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.45 |
| ▸ | PDE9A | O76083 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10084040 | 0.89 | PDE5A (0.59) | PDE5APDE3BPDE3ASMN1; SMN2LMNA | |
| SCHEMBL38373 | 0.89 | PDE5A (0.61) | PDE5APDE3BPDE3ASMN1; SMN2KMT2A | |
| SCHEMBL10083509 | 0.88 | PDE5A (0.58) | PDE5APDE3BPDE3ALMNAKMT2A | |
| SCHEMBL38484 | 0.87 | PDE5A (0.57) | PDE5APDE3BPDE3ASMN1; SMN2LMNA | |
| SCHEMBL37798 | 0.86 | PDE5A (1.00) | PDE5ASMN1; SMN2LMNAKMT2AMAPT | |
| SCHEMBL46296 | 0.86 | PDE5A (0.56) | PDE5APDE3BPDE3ASMN1; SMN2LMNA | |
| SCHEMBL37864 | 0.85 | PDE5A (0.82) | PDE5APDE3BPDE3ASMN1; SMN2LMNA | |
| SCHEMBL37626 | 0.85 | PDE5A (0.80) | PDE5APDE3BPDE3ASMN1; SMN2LMNA | |
| SCHEMBL4515609 | 0.84 | PDE5A (0.76) | PDE5APDE3BPDE3ASMN1; SMN2LMNA | |
| SCHEMBL46291 | 0.82 | PDE5A (0.50) | PDE5ALMNAKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |