Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 15/20 | 0.40 |
| ▸ | FNTB | P49356 | 15/20 | 0.40 |
| ▸ | PGGT1B | P53609 | 6/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | MC4R | P32245 | 2/20 | 0.33 |
| ▸ | MC1R | Q01726 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2381616 | 0.94 | FNTA (0.47) | FNTAFNTBPGGT1BCYP19A1KCNH2 | |
| Trifluoroacetic Acid SCHEMBL8162228 | 0.89 | FNTA (0.43) | FNTAFNTBPGGT1BCYP19A1KCNH2 | |
| SCHEMBL445939 | 0.84 | FNTA (0.51) | FNTAFNTBPGGT1BCYP19A1MC4R | |
| SCHEMBL5131468 | 0.84 | FNTA (0.51) | FNTAFNTBPGGT1BCYP19A1MC4R | |
| Hydrochloric Acid SCHEMBL8160943 | 0.84 | FNTA (0.51) | FNTAFNTBPGGT1BCYP19A1MC4R | |
| Hydrochloric Acid SCHEMBL8541088 | 0.84 | FNTA (0.51) | FNTAFNTBPGGT1BCYP19A1MC4R | |
| SCHEMBL5551508 | 0.83 | FNTA (0.44) | FNTAFNTBPGGT1BKCNH2GRM2 | |
| SCHEMBL2370713 | 0.80 | FNTA (0.45) | FNTAFNTBPGGT1BCYP19A1 | |
| SCHEMBL6965295 | 0.80 | CYP19A1 (0.36) | FNTAFNTBPGGT1BCYP19A1KCNH2 | |
| SCHEMBL3517007 | 0.79 | FNTA (0.50) | FNTAFNTBPGGT1BCYP19A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132198-A1 | SOLID FORMS OF A RAF KINASE INHIBITOR | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008140850-A1 | SOLID FORMS OF A RAF KINASE INHIBITOR | NOVARTIS AG (CH) | 2008-11-20 | — | — | WO | disclosed |
| EP-1611088-A2 | HYDROXAMATES AS THERAPEUTIC AGENTS | AXYS PHARMACEUTICALS, INC. (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2005097770-A1 | NOVEL HYDROXAMATES AS THERAPEUTIC AGENTS | PHARMACYCLICS, INC. (US) | 2005-10-20 | — | — | WO | disclosed |
| EP-1259236-A4 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2004092115-A2 | HYDROXAMATES AS THERAPEUTIC AGENTS | AXYS PHARMACEUTICALS INC. (US) | 2004-10-28 | — | — | WO | disclosed |
| WO-2003090680-A2 | NOVEL PHENYL DERIVATIVES AS INDUCERS OF APOPTOSIS | AXYS PHARMACEUTICALS, INC. (US) | 2003-11-06 | — | — | WO | disclosed |
| EP-1259236-A1 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001062252-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2001-08-30 | — | — | WO | disclosed |