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Arginine

Arginine

SCHEMBL4405153

CC[C@H](C)[C@H](N)C(=O)Oc1ccc(C[C@H](N)C(=O)OC(=O)[C@@H](N)CCCNC(=N)N)cc1.N=C(N)NCCC[C@H](N)C(=O)O.NCC(=O)O.NCC(=O)O.NCC(=O)OC[C@H](N)C(=O)O.N[C@@H](CC(=O)O)C(=O)O

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ NPY4R P50391 11/20 0.36
▸ NPY1R P25929 6/20 0.36
▸ NPY2R P49146 4/20 0.36
▸ NPY5R Q15761 4/20 0.36
▸ GRB2 P62993 3/20 0.32
▸ SLC7A5 Q01650 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Glycine SCHEMBL5344900 0.96 NPY4R (0.38) NPY4RNPY1RNPY2RNPY5RGRB2
SCHEMBL2674971 0.95 NPY4R (0.39) NPY4RNPY1RNPY2RNPY5RGRB2
Serine SCHEMBL675717 0.88 NPY4R (0.39) NPY4RNPY1RNPY2RNPY5RGRB2
Glycine SCHEMBL9511974 0.88 NPY4R (0.40) NPY4RNPY1RNPY2RNPY5RGRB2
Serine SCHEMBL15752146 0.85 NPY4R (0.41) NPY4RNPY1RNPY2RNPY5RGRB2
Arginine SCHEMBL6808147 0.84 NPY4R (0.45) NPY4RNPY1RNPY2RNPY5RSLC7A5
Serine SCHEMBL9509964 0.83 NPY4R (0.38) NPY4RNPY1RNPY2RNPY5RGRB2
Arginine SCHEMBL1137072 0.81 NPY4R (0.32) NPY4RNPY1RNPY2RNPY5R
Serine SCHEMBL9512908 0.81 NPY4R (0.40) NPY4RNPY1RNPY2RNPY5RGRB2
Aspartic Acid SCHEMBL9511966 0.81 MAPK8 (0.33) NPY4RNPY1RNPY2RNPY5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8518105-B2 Methods and apparatuses for coating a lesion ABBOTT CARDIOVASCULAR SYSTEM INC. (US) 2013-08-27 — — US disclosed
US-20090005849-A1 Methods and apparatuses for coating a lesion ABBOTT CARDIOVASCULAR SYSTEMS INC. 2009-01-01 — — US disclosed