Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Serine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 15/20 | 0.40 |
| ▸ | NPY1R | P25929 | 9/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 7/20 | 0.39 |
| ▸ | NPY2R | P49146 | 5/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | GRB2 | P62993 | 1/20 | 0.33 |
| ▸ | KISS1R | Q969F8 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Serine SCHEMBL675717 | 0.93 | NPY4R (0.39) | NPY4RNPY1RNPY5RNPY2RSLC7A5 | |
| Arginine SCHEMBL6808147 | 0.90 | NPY4R (0.45) | NPY4RNPY1RNPY5RNPY2RSLC7A5 | |
| Glycine SCHEMBL9511974 | 0.89 | NPY4R (0.40) | NPY4RNPY1RNPY5RNPY2RSLC7A5 | |
| Serine SCHEMBL15752146 | 0.89 | NPY4R (0.41) | NPY4RNPY1RNPY5RNPY2RSLC7A5 | |
| Glycine SCHEMBL5344900 | 0.84 | NPY4R (0.38) | NPY4RNPY1RNPY5RNPY2RSLC7A5 | |
| Serine SCHEMBL9509964 | 0.84 | NPY4R (0.38) | NPY4RNPY1RNPY5RNPY2RSLC7A5 | |
| Tyrosine SCHEMBL27616071 | 0.84 | NPY4R (0.46) | NPY4RNPY1RNPY5RNPY2RSLC7A5 | |
| Tyrosine SCHEMBL27510324 | 0.84 | NPY4R (0.46) | NPY4RNPY1RNPY5RNPY2RSLC7A5 | |
| Aspartic Acid SCHEMBL10457651 | 0.84 | SLC7A5 (0.39) | NPY4RNPY1RNPY5RNPY2RSLC7A5 | |
| Glycine SCHEMBL5579222 | 0.83 | ITGB3 (0.45) | NPY4RNPY1RNPY5RNPY2RSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0278781-B1 | Peptides with laminin activity | US COMMERCE (US) | 1993-11-03 | — | — | EP | disclosed |
| WO-1988006039-A1 | PEPTIDES WITH LAMININ ACTIVITY | UNITED STATES OF AMERICA, REPRESENTED BY THE UNITE (US) | 1988-08-25 | — | — | WO | disclosed |
| EP-0278781-A2 | Peptides with laminin activity | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce (US) | 1988-08-17 | — | — | EP | disclosed |