Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 13/20 | 0.38 |
| ▸ | NPY1R | P25929 | 7/20 | 0.38 |
| ▸ | NPY2R | P49146 | 5/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.33 |
| ▸ | GRB2 | P62993 | 3/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2674971 | 0.98 | NPY4R (0.39) | NPY4RNPY1RNPY2RNPY5RSLC7A5 | |
| Arginine SCHEMBL4405153 | 0.96 | NPY4R (0.36) | NPY4RNPY1RNPY2RNPY5RSLC7A5 | |
| Serine SCHEMBL675717 | 0.92 | NPY4R (0.39) | NPY4RNPY1RNPY2RNPY5RSLC7A5 | |
| Glycine SCHEMBL9511974 | 0.91 | NPY4R (0.40) | NPY4RNPY1RNPY2RNPY5RSLC7A5 | |
| Serine SCHEMBL15752146 | 0.88 | NPY4R (0.41) | NPY4RNPY1RNPY2RNPY5RSLC7A5 | |
| Serine SCHEMBL9509964 | 0.86 | NPY4R (0.38) | NPY4RNPY1RNPY2RNPY5RSLC7A5 | |
| Arginine SCHEMBL6808147 | 0.85 | NPY4R (0.45) | NPY4RNPY1RNPY2RNPY5RSLC7A5 | |
| Serine SCHEMBL9512908 | 0.84 | NPY4R (0.40) | NPY4RNPY1RNPY2RNPY5RSLC7A5 | |
| SCHEMBL995485 | 0.82 | NPY4R (0.36) | NPY4RNPY1RNPY2RNPY5RSLC7A5 | |
| Glycine SCHEMBL5579222 | 0.81 | ITGB3 (0.45) | NPY4RNPY1RNPY2RNPY5RSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007112048-A2 | METHODS AND APPARATUSES FOR COATING A LESION | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2007-10-04 | — | — | WO | disclosed |