Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4400749 | 0.88 | PTGER1 (0.34) | MEN1KMT2ALMNAALDH1A1MAPT | |
| SCHEMBL914650 | 0.87 | MEN1 (0.47) | CCR5CCR2MEN1KMT2ALMNA | |
| SCHEMBL4411253 | 0.81 | LMNA (0.35) | LMNAALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL4409139 | 0.76 | ADRB3 (0.41) | MEN1KMT2AADRB3PTGER1 | |
| SCHEMBL914632 | 0.75 | KMT2A (0.47) | MEN1KMT2ALMNAALDH1A1MAPT | |
| SCHEMBL914267 | 0.71 | KDM4E (0.38) | MEN1KMT2ALMNAALDH1A1NPC1 | |
| SCHEMBL6963102 | 0.71 | KDM4E (0.38) | MEN1KMT2ALMNAALDH1A1NPC1 | |
| SCHEMBL12905932 | 0.70 | KMT2A (0.38) | MEN1KMT2ALMNAALDH1A1NPC1 | |
| SCHEMBL17571837 | 0.68 | NPC1 (0.53) | CCR5CCR2LMNAALDH1A1NPC1 | |
| SCHEMBL7216495 | 0.68 | CCR5 (0.52) | CCR5CCR2ALDH1A1MAPTCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |