SCHEMBL440625

SCHEMBL440625

C=C(CCCc1cccc(Cl)c1)C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PLAAT3 P53816 3/20 0.57
PLAAT5 Q96KN8 3/20 0.57
PLAAT2 Q9NWW9 3/20 0.57
PLAAT4 Q9UL19 3/20 0.57
SMN1; SMN2 Q16637 2/20 0.51
ALDH1A1 P00352 3/20 0.50
KMT2A Q03164 2/20 0.50
CTBP2 P56545 1/20 0.49
MEN1 O00255 1/20 0.48
HPGD P15428 1/20 0.48
HTR3E A5X5Y0 1/20 0.47
HTR3B O95264 1/20 0.47
HTR3A P46098 1/20 0.47
HTR3D Q70Z44 1/20 0.47
HTR3C Q8WXA8 1/20 0.47
NAAA Q02083 2/20 0.46
TAAR1 Q96RJ0 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1919956 0.90 PLAAT3 (0.54) PLAAT3PLAAT5PLAAT2PLAAT4SMN1; SMN2
SCHEMBL17940814 0.84 HDAC1 (0.55) PLAAT3PLAAT5PLAAT2PLAAT4SMN1; SMN2
SCHEMBL5024832 0.83 SMN1; SMN2 (0.68) PLAAT3PLAAT5PLAAT2PLAAT4SMN1; SMN2
SCHEMBL1137526 0.83 HDAC6 (0.54) SMN1; SMN2CTBP2TAAR1
SCHEMBL27472305 0.82 PLAAT3 (0.60) PLAAT3PLAAT5PLAAT2PLAAT4SMN1; SMN2
SCHEMBL114130 0.81 HDAC1 (0.64) PLAAT3PLAAT5PLAAT2PLAAT4SMN1; SMN2
SCHEMBL4666437 0.81 HDAC1 (0.64) PLAAT3PLAAT5PLAAT2PLAAT4SMN1; SMN2
SCHEMBL445493 0.81 HDAC1 (0.47) PLAAT3PLAAT5PLAAT2PLAAT4SMN1; SMN2
SCHEMBL679742 0.81 NPC1 (0.52) PLAAT3PLAAT5PLAAT2PLAAT4SMN1; SMN2
SCHEMBL19656181 0.81 TAAR1 (0.46) PLAAT3PLAAT5PLAAT2PLAAT4SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4121802-B1 HIGH REFRACTIVE INDEX SILOXANE INSERT MATERIALS FOR EMBEDDED CONTACT LENSES ALCON INC (CH) 2024-07-17 EP claimed
EP-3728339-B1 COMPOSITION FOR OPHTHALMOLOGICAL PRODUCTS AMO Ireland (IE) 2022-07-06 EP claimed
EP-2303331-B1 OPHTHALMIC DEVICE HAVING THERAPEUTIC AGENT DELIVERY CAPABILITY AND METHOD OF FORMING SAME ALCON INC (CH) 2022-01-26 EP claimed
EP-3200840-B1 LOW-WATER CONTENT ACRYLATE-ACRYLAMIDE COPOLYMERS FOR OPHTHALMIC DEVICES ALCON INC (CH) 2021-11-17 EP claimed
EP-3200839-B1 HYDROPHOBIC ACRYLATE-ACRYLAMIDE COPOLYMERS FOR OPHTHALMIC DEVICES NOVARTIS AG (CH) 2019-09-04 EP claimed
EP-3223870-B1 WET-PACK INTRAOCULAR LENS MATERIALS WITH HIGH REFRACTIVE INDEX NOVARTIS AG (CH) 2018-09-26 EP claimed
EP-3077016-B1 SOFT ACRYLIC MATERIALS WITH HIGH REFRACTIVE INDEX AND MINIMIZED GLISTENING NOVARTIS AG (CH) 2018-05-16 EP claimed
EP-2292672-B1 Biocompatible polymers and co-polymers comprising amino acids in the side chain CIS PHARMA AG (CH) 2018-05-09 EP claimed
EP-1888660-B1 BIOCOMPATIBLE POLYMERS AND CO-POLYMERS COMPRISING AMINO ACIDS IN THE SIDE CHAIN CIS PHARMA AG (CH) 2017-05-17 EP claimed
EP-2407511-B1 Thermoplastic resin composition CHEIL IND INC (KR) 2017-03-22 EP claimed
US-20110281995-A1 Polycarbonate Resin Composition and Molded Product Using the Same CHEIL INDUSTRIES INC. (KR) 2011-11-17 US claimed
EP-2341102-A1 Thermoplastic resin composition revealing improved impact strength and melt flow property Cheil Industries Inc. (KR) 2011-07-06 EP claimed
US-20110160377-A1 Thermoplastic Resin Composition Having Improved Impact Strength and Melt Flow Properties CHEIL INDUSTRIES INC. (KR) 2011-06-30 US claimed
EP-2225325-B1 HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS ALCON INC (CH) 2011-06-01 EP claimed
US-20100160559-A1 Polylactic Acid/Polycarbonate Resin Composition and Molded Product Made Using the Same CHEIL INDUSTRIES INC. (KR) 2010-06-24 US claimed
EP-2199342-A2 Polylactic acid/polycarbonate resin composition and molded product made using the same Cheil Industries Inc. (KR) 2010-06-23 EP claimed
EP-1080382-B1 HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS ALCON INC (CH) 2009-07-08 EP claimed
EP-1664855-B1 PROCESS FOR MANUFACTURING INTRAOCULAR LENSES WITH BLUE LIGHT ABSORPTION CHARACTERISTICS BAUSCH & LOMB (US) 2009-03-11 EP claimed
EP-1177227-B1 WATER PLASTICIZED HIGH REFRACTIVE INDEX POLYMER FOR OPHTHALMIC APPLICATIONS SURGIDEV CORP (US) 2003-10-01 EP claimed
EP-0914169-B1 MATERIALS FOR USE IN GLAUCOMA FILTRATION DEVICES ALCON LAB INC (US) 2003-07-30 EP claimed