Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 2/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 3/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4408663 | 0.90 | RIPK1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4412959 | 0.84 | TACR1 (0.44) | TACR1FFAR4 | |
| SCHEMBL2148828 | 0.83 | RIPK1 (0.48) | MEN1KMT2ATACR1NR1H2NR1H3 | |
| SCHEMBL2708227 | 0.82 | MEN1 (0.43) | MEN1KMT2ATACR1NR1H2NR1H3 | |
| SCHEMBL12979900 | 0.82 | MEN1 (0.43) | MEN1KMT2ATACR1NR1H2NR1H3 | |
| SCHEMBL2708229 | 0.82 | MEN1 (0.43) | MEN1KMT2ATACR1NR1H2NR1H3 | |
| SCHEMBL3714076 | 0.81 | MEN1 (0.39) | MEN1KMT2ATACR1NR1H2NR1H3 | |
| SCHEMBL2708184 | 0.81 | MEN1 (0.39) | MEN1KMT2ATACR1NR1H2NR1H3 | |
| SCHEMBL20449101 | 0.81 | MEN1 (0.42) | MEN1KMT2ATACR1NR1H2NR1H3 | |
| SCHEMBL20528419 | 0.81 | MEN1 (0.42) | MEN1KMT2ATACR1NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558577-B1 | SUBSTITUTED 4-PHENYL-PIPERIDIN-AMIDES AS TACHYKININ ANTAGONISTS AND SEROTONIN REPTAKE INHIBITORS | GLAXO GROUP LTD (GB) | 2009-12-30 | — | — | EP | disclosed |
| US-20080262041-A1 | Beta-Lactams for Treatment of Cns Disorders | GLAXO GROUP LIMITED (GB) | 2008-10-23 | — | — | US | disclosed |
| EP-1689737-B1 | BETA-LACTAMS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LTD (GB) | 2008-07-16 | — | — | EP | disclosed |
| US-20060128752-A1 | Chemical compounds | GLAXO GROUP LIMITED (GB) | 2006-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262041-A1 | Beta-Lactams for Treatment of Cns Disorders | SLC7A1, TPH1, CHRNA10 | PSEN1 788/4885PSEN2 1581/4885APH1B 857/4885 |
| US-20060128752-A1 | Chemical compounds | HTR7, NPSR1, TACR2 | PSEN1 2594/4885PSEN2 2226/4885APH1B 4637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.