Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10784001 | 0.90 | ACHE (0.55) | PKMPOLBLMNAACHEHSD17B10 | |
| SCHEMBL10784036 | 0.87 | CYP2C9 (0.44) | PKMNR1I2POLBLMNAHSD17B10 | |
| SCHEMBL10785934 | 0.87 | NR1I2 (0.46) | PKMNR1I2LMNAACHEHSD17B10 | |
| SCHEMBL10785872 | 0.84 | CYP1A2 (0.58) | NR1I2ACHEKDM4ECYP3A4CYP2C9 | |
| SCHEMBL10790585 | 0.84 | ADORA3 (0.55) | POLBACHEHSD17B10KDM4EALDH1A1 | |
| SCHEMBL10789033 | 0.83 | ADORA3 (0.69) | NR1I2POLBLMNAACHEHSD17B10 | |
| SCHEMBL31295852 | 0.83 | NR3C2 (0.47) | PKMNR1I2POLBHSD17B10KDM4E | |
| SCHEMBL10786737 | 0.83 | ALDH1A1 (0.60) | PKMNR1I2POLBLMNAHSD17B10 | |
| SCHEMBL10789570 | 0.82 | HSD17B10 (0.46) | PKMNR1I2POLBLMNAHSD17B10 | |
| SCHEMBL10784567 | 0.81 | ALDH1A1 (0.47) | PKMNR1I2POLBLMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056934-A1 | 1,4-DIHYDRONAPHTHYRIDINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2009-05-07 | — | — | WO | disclosed |