Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.55 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SELP | P16109 | 2/20 | 0.45 |
| ▸ | SELE | P16581 | 2/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | SELL | P14151 | 1/20 | 0.43 |
| ▸ | GLS | O94925 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23518466 | 0.91 | ITGB3 (0.50) | ATMITGB3ITGA2BLMNASELP | |
| SCHEMBL7864280 | 0.81 | ITGB3 (0.62) | ITGB3ITGA2BLMNASELPSELE | |
| SCHEMBL288541 | 0.81 | ITGB3 (0.61) | ITGB3ITGA2BLMNASELPSELE | |
| SCHEMBL9827968 | 0.77 | ATM (0.90) | ATMLMNATSHRTRPV1SMN1; SMN2 | |
| SCHEMBL8407707 | 0.76 | HDAC6 (0.61) | TSHRSMN1; SMN2HPGDHDAC3HDAC4 | |
| SCHEMBL6349089 | 0.76 | ATM (0.87) | ATMLMNATSHRTRPV1HPGD | |
| SCHEMBL5656019 | 0.76 | ATM (0.87) | ATMLMNATSHRTRPV1HPGD | |
| SCHEMBL1065668 | 0.76 | ATM (0.70) | ATMLMNATSHRTRPV1SMN1; SMN2 | |
| SCHEMBL8407713 | 0.76 | ITGB3 (0.54) | ITGB3ITGA2BEPHX1HDAC3HDAC4 | |
| SCHEMBL10587170 | 0.75 | TRPV1 (0.67) | ATMTRPV1SMN1; SMN2HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629319-B2 | Heteroaryl peptidomimetics as thrombin receptor antagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-12-08 | — | — | US | disclosed |
| US-7618945-B2 | Heteroaryl peptidomimetics as thrombin receptor antagonists | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-11-17 | — | — | US | disclosed |
| US-20060009396-A1 | Novel heteroaryl peptidomimetics as thrombin receptor antagonists | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-01-12 | — | — | US | disclosed |
| EP-1578786-A2 | HETEROARYL PEPTIDOMIMETICS AS THROMBIN RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004060913-A2 | HETEROARYL PEPTIDOMIMETICS AS THROMBIN RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-07-22 | — | — | WO | disclosed |
| US-20040138141-A1 | Novel heteroaryl peptidomimetics as thrombin receptor antagonists | JANSSEN PHARMACEUTICA, NV (BE) | 2004-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060009396-A1 | Novel heteroaryl peptidomimetics as thrombin receptor antagonists | PTAFR, F2R, F2RL1 | ATM 1705/4885ITGB3 481/4885ITGA2B 932/4885 |
| US-20040138141-A1 | Novel heteroaryl peptidomimetics as thrombin receptor antagonists | PTAFR, F2R, F2RL1 | ATM 1705/4885ITGB3 481/4885ITGA2B 932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.