Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10712987 | 0.84 | CYP3A4 (0.61) | CYP3A4MAPTMAOBALOX5PTGS2 | |
| SCHEMBL4401870 | 0.79 | ALDH1A1 (0.43) | CYP3A4MAPTALDH1A1TDP1L3MBTL1 | |
| SCHEMBL21729821 | 0.78 | PTGS2 (0.57) | CYP3A4MAPTMAOBALOX5PTGS2 | |
| SCHEMBL19921723 | 0.78 | CYP3A4 (0.54) | CYP3A4MAPTMAOBALOX5PTGS2 | |
| SCHEMBL3228491 | 0.77 | ALDH1A1 (0.52) | CYP3A4MAPTALDH1A1TDP1L3MBTL1 | |
| SCHEMBL4406554 | 0.77 | ALDH1A1 (0.50) | CYP3A4MAPTALDH1A1TDP1L3MBTL1 | |
| SCHEMBL29513975 | 0.77 | ALDH1A1 (0.50) | CYP3A4MAPTALDH1A1TDP1L3MBTL1 | |
| SCHEMBL28729178 | 0.77 | CA12 (0.45) | CYP3A4ALDH1A1TDP1HSD17B10ESR2 | |
| SCHEMBL23702702 | 0.75 | POLB (0.47) | CYP3A4MAPTALDH1A1TDP1L3MBTL1 | |
| SCHEMBL16659617 | 0.75 | CYP3A4 (0.50) | CYP3A4MAPTMAOBALOX5PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11155555-B2 | Compounds | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-26 | — | — | US | disclosed |
| US-20200255430-A1 | NEW COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2020-08-13 | — | — | US | disclosed |
| EP-3353177-B1 | TRICYCLIC HETEROCYCLES FOR THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA NV (BE) | 2020-06-03 | — | — | EP | disclosed |
| WO-2017050864-A1 | NEW COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-30 | — | — | WO | disclosed |
| EP-1549651-B1 | PYRIMIDOPYRIMIDONES AS KINASE INHIBITORS | WARNER LAMBERT CO (US) | 2009-12-23 | — | — | EP | disclosed |
| US-7196090-B2 | Kinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2007-03-27 | — | — | US | disclosed |
| EP-1549651-A1 | KINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011465-A1 | KINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-05 | — | — | WO | disclosed |
| US-20040019210-A1 | Kinase inhibitors | CHIVIKAS CONNOLLY CLEO J (US) | 2004-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019210-A1 | Kinase inhibitors | CDK2, CDK1, CDK4 | CYP3A4 2224/4885MAPT 3541/4885MAOB 1173/4885 |
| US-11155555-B2 | Compounds | NQO2, NQO1, SDHA | CYP3A4 84/4885MAPT 2060/4885MAOB 762/4885 |
| US-20200255430-A1 | NEW COMPOUNDS | NQO2, NQO1, SDHA | CYP3A4 125/4885MAPT 2069/4885MAOB 786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.