SCHEMBL4407869

SCHEMBL4407869

CCc1c(Cl)ccc(O)c1C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.39
MAPK1 P28482 1/20 0.39
ESR2 Q92731 4/20 0.39
ESR1 P03372 3/20 0.39
SHBG P04278 1/20 0.36
TRPA1 O75762 2/20 0.35
TYR P14679 1/20 0.35
HSD17B10 Q99714 3/20 0.33
ALDH1A1 P00352 2/20 0.33
TSHR P16473 2/20 0.33
HTR1D P28221 1/20 0.33
HTR1B P28222 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
HSP90AA1 P07900 1/20 0.33
HSP90AB1 P08238 1/20 0.33
KDM4E B2RXH2 1/20 0.33
GLA P06280 1/20 0.33
GAA P10253 1/20 0.33
HPGD P15428 1/20 0.33
CASP1 P29466 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL664026 0.83 CYP3A4 (0.39) CYP3A4MAPK1ESR2ESR1SHBG
SCHEMBL27695109 0.82 CYP3A4 (0.54) CYP3A4MAPK1ESR2ESR1TRPA1
SCHEMBL648577 0.81 ESR1 (0.47) ESR2ESR1TRPA1TYRHSD17B10
SCHEMBL11891680 0.81 ALDH1A1 (0.36) ALDH1A1
Benzene SCHEMBL573759 0.79 ESR2 (0.37) CYP3A4MAPK1ESR2ESR1SHBG
SCHEMBL11717676 0.77 NOS3 (0.33) CYP3A4ALDH1A1
SCHEMBL2321269 0.77 HTR1D (0.46) ESR2ESR1TRPA1TYRHSD17B10
SCHEMBL3685532 0.77 CA1 (0.39) CYP3A4MAPK1TRPA1HSD17B10ALDH1A1
SCHEMBL17232487 0.77 ESR1 (0.41) CYP3A4MAPK1ESR2ESR1TRPA1
SCHEMBL2428410 0.77 CYP3A4 (0.38) CYP3A4MAPK1ESR2ESR1TRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2136648-A1 CENTER-FILLED CHEWING GUM PRODUCT FOR DENTAL CARE Gumlink A/S (DK) 2009-12-30 EP disclosed
WO-2008122286-A1 CENTER-FILLED CHEWING GUM PRODUCT FOR DENTAL CARE GUMLINK A/S (DK) 2008-10-16 WO disclosed