Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 4/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL573759 | 0.96 | ESR2 (0.37) | CYP3A4MAPK1ESR1ESR2HSD17B10 | |
| SCHEMBL875815 | 0.83 | CNR1 (0.38) | CYP3A4MAPK1ESR1ESR2HPGD | |
| SCHEMBL4407869 | 0.83 | CYP3A4 (0.39) | CYP3A4MAPK1ESR1ESR2HSD17B10 | |
| SCHEMBL2166705 | 0.82 | MAPK1 (0.46) | CYP3A4MAPK1ESR1ESR2KDM4E | |
| SCHEMBL648577 | 0.81 | ESR1 (0.47) | ESR1ESR2HSD17B10ALDH1A1KDM4E | |
| SCHEMBL11891680 | 0.81 | ALDH1A1 (0.36) | ALDH1A1TP53CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL23227095 | 0.80 | CYP3A4 (0.52) | CYP3A4MAPK1ESR1ESR2HSD17B10 | |
| SCHEMBL2168406 | 0.79 | TYR (0.53) | CYP3A4ESR1HSD17B10ALDH1A1KDM4E | |
| SCHEMBL17232508 | 0.77 | NOS3 (0.38) | CYP3A4ALDH1A1 | |
| SCHEMBL983528 | 0.77 | ESR1 (0.41) | ESR1ESR2HSD17B10ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203063-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. | 2023-06-29 | — | — | US | disclosed |
| CN-107743421-B | Apparatus and method for applying a composition to a surface | 宝洁公司 | 2021-02-09 | — | — | CN | disclosed |
| CN-112118831-A | Tabletted chewing gum suitable for active pharmaceutical ingredients | 费尔廷制药公司 | 2020-12-22 | — | — | CN | disclosed |
| CN-110650721-A | Coated particles and uses thereof | 强生消费者公司 | 2020-01-03 | — | — | CN | disclosed |
| CN-109414432-A | Antimicrobial compounds and methods of use thereof | 港大科桥有限公司 | 2019-03-01 | — | — | CN | disclosed |
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
| US-8063105-B2 | Renin inhibitors | MERCK CANADA INC. (CA) | 2011-11-22 | — | — | US | disclosed |
| US-20090281103-A1 | Renin Inhibitors | MERCK CANADA INC. (CA) | 2009-11-12 | — | — | US | disclosed |
| EP-1910272-A1 | RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007009250-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-01-25 | — | — | WO | disclosed |
| WO-1994026245-A1 | ORAL CARE COMPOSITIONS CONTAINING ZINC OXIDE PARTICLES | CHURCH & DWIGHT CO., INC. (US) | 1994-11-24 | — | — | WO | disclosed |
| WO-1994026244-A1 | ORAL CARE COMPOSITIONS CONTAINING ZINC OXIDE PARTICLES AND SODIUM BICARBONATE | CHURCH & DWIGHT CO., INC. (US) | 1994-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | CYP3A4 774/4885MAPK1 830/4885ESR1 3018/4885 |
| US-20230203063-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | TYMS, TYMP, DHFR | CYP3A4 45/4885MAPK1 2326/4885ESR1 3242/4885 |
| US-20090281103-A1 | Renin Inhibitors | REN, ACE, AGT | CYP3A4 531/4885MAPK1 497/4885ESR1 4199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.