Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2381495 | 1.00 | AGTR2 (0.54) | AGTR2ALDH1A1BCHEMAOBKDM4E | |
| SCHEMBL1983977 | 0.90 | AGTR2 (0.53) | AGTR2ALDH1A1BCHEMAOBKDM4E | |
| SCHEMBL1983978 | 0.90 | AGTR2 (0.53) | AGTR2ALDH1A1BCHEMAOBKDM4E | |
| SCHEMBL1987132 | 0.90 | AGTR2 (0.53) | AGTR2ALDH1A1BCHEMAOBKDM4E | |
| SCHEMBL13117075 | 0.85 | L3MBTL1 (0.51) | AGTR2ALDH1A1BCHEMAOBKDM4E | |
| SCHEMBL13102888 | 0.85 | L3MBTL1 (0.51) | AGTR2ALDH1A1BCHEMAOBKDM4E | |
| SCHEMBL18204011 | 0.84 | DRD2 (0.41) | AGTR2ALDH1A1KDM4EHPGDCYP2D6 | |
| SCHEMBL18204010 | 0.84 | DRD2 (0.41) | AGTR2ALDH1A1KDM4EHPGDCYP2D6 | |
| SCHEMBL2381394 | 0.83 | AGTR2 (0.48) | AGTR2ALDH1A1BCHEMAOBKDM4E | |
| SCHEMBL1984795 | 0.83 | AGTR2 (0.48) | AGTR2ALDH1A1BCHEMAOBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009068512-A1 | 2 -AMINO-PYRIMIDINE DERIVATIVES AS HISTAMINE H4 ANTAGONISTS | PALAU PHARMA, S. A. (ES) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009056551-A1 | FURO[3,2-D]PYRIMIDINE DERIVATIVES | PALAU PHARMA, S. A. (ES) | 2009-05-07 | — | — | WO | disclosed |