Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27398574 | 0.80 | PTK2 (0.51) | PTK2SCN9ASCN2ASCN3ASCN10A | |
| SCHEMBL11711087 | 0.78 | PTK2 (0.49) | PTK2SCN9ASCN2ASCN3ASCN10A | |
| SCHEMBL13175197 | 0.76 | KDM4E (0.45) | PTK2ADORA3KDM4ELMNAADORA2B | |
| SCHEMBL5365213 | 0.75 | XIAP (0.51) | PTK2SCN9ASCN2ASCN3ASCN10A | |
| SCHEMBL11491259 | 0.71 | XIAP (0.68) | ADORA3KDM4ELMNAADORA2BADORA1 | |
| SCHEMBL11632340 | 0.70 | L3MBTL1 (0.46) | PTK2SCN9ASCN2ASCN3ASCN10A | |
| SCHEMBL28545686 | 0.70 | PTK2 (0.51) | PTK2SCN9ASCN2ASCN3ASCN10A | |
| SCHEMBL10129558 | 0.70 | MAPK8 (0.45) | PTK2SCN9ASCN2ASCN3ASCN10A | |
| SCHEMBL5363593 | 0.70 | XIAP (0.52) | PTK2SCN9ASCN2ASCN3ASCN10A | |
| SCHEMBL9753194 | 0.70 | SORT1 (0.53) | PTK2ADORA3KDM4ELMNAADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2133340-B1 | Novel benzazepine derivatives | GLAXO GROUP LTD (GB) | 2013-01-16 | — | — | EP | disclosed |
| EP-2133340-A1 | Novel benzazepine derivatives | Glaxo Group Limited (GB) | 2009-12-16 | — | — | EP | disclosed |