Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL246231 | 0.78 | LATS1 (0.43) | KDM4ELATS1IDO1LATS2CHUK | |
| SCHEMBL23717024 | 0.78 | MAOA (0.43) | MAOAPOLBSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2539705 | 0.77 | HPGD (0.62) | POLBSMN1; SMN2ALDH1A1HPGDMAPT | |
| SCHEMBL28598438 | 0.76 | HPGD (0.60) | POLBSMN1; SMN2ALDH1A1HPGDMAPT | |
| SCHEMBL15578467 | 0.75 | ALDH1A1 (0.59) | POLBSMN1; SMN2ALDH1A1HPGDMAPT | |
| SCHEMBL28389107 | 0.75 | LATS1 (0.45) | LATS1IDO1LATS2 | |
| SCHEMBL13622775 | 0.75 | ACHE (0.42) | POLBSMN1; SMN2ALDH1A1HPGDMAPT | |
| SCHEMBL28393257 | 0.73 | LATS1 (0.43) | LMNALATS1LATS2 | |
| SCHEMBL26329083 | 0.73 | CA12 (0.44) | MAOAALDH1A1HPGDMAPTPDGFRB | |
| SCHEMBL2533905 | 0.72 | IGF1R (0.51) | POLBSMN1; SMN2ALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2133340-B1 | Novel benzazepine derivatives | GLAXO GROUP LTD (GB) | 2013-01-16 | — | — | EP | disclosed |
| EP-2133340-A1 | Novel benzazepine derivatives | Glaxo Group Limited (GB) | 2009-12-16 | — | — | EP | disclosed |