SCHEMBL440956

SCHEMBL440956

CCCC(C=O)C(=O)O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10619730 1.00
SCHEMBL3640067 0.98 CHRM1 (0.48)
SCHEMBL3637192 0.98 CHRM1 (0.48)
SCHEMBL2053946 0.86 CA2 (0.50)
SCHEMBL284704 0.84 GPR84 (0.52)
SCHEMBL15621929 0.84 GPR84 (0.52)
SCHEMBL15622058 0.84 GPR84 (0.52)
SCHEMBL17065011 0.82 GPR84 (0.55)
SCHEMBL4565528 0.82 GPR84 (0.55)
SCHEMBL10593068 0.82 GPR84 (0.55)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 311 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240238230-A1 METHODS OF MODULATION OF BRANCHED CHAIN ACIDS AND USES THEREOF BAYLOR COLLEGE OF MEDICINE 2024-07-18 US claimed
US-11786494-B2 Methods of modulation of branched chain acids and uses thereof BAYLOR COLLEGE OF MEDICINE (US) 2023-10-17 US claimed
US-20210349103-A1 METABOLIC BIOMARKERS OF NAFLD/NASH AND RELATED DISEASE PHENOTYPES AND METHODS OF USING SAME DUKE UNIVERSITY 2021-11-11 US claimed
US-20200147016-A1 METHODS OF MODULATION OF BRANCHED CHAIN ACIDS AND USES THEREOF ACER THERAPEUTICS INC. 2020-05-14 US claimed
CN-110520537-A Method for generating methyl methacrylate LUCITE INT UK LTD 2019-11-29 CN claimed
US-20190151268-A1 METHODS OF MODULATION OF BRANCHED CHAIN ACIDS AND USES THEREOF ACER THERAPEUTICS INC. 2019-05-23 US claimed
US-10113190-B2 Method for producing L-leucine, L-valine, L-isoleucine, α-ketoisovalerate, α-keto-beta-methylvalerate, or α-ketoisocaproate using recombinant Corynebacteria that contain the ilvBN operon which can be induced by propionate EVONIK DEGUSSA GMBH (DE) 2018-10-30 US claimed
EP-3383379-A1 COCOA POLYPHENOLS AND SOLUBLE DIETARY FIBER FOR USE IN THE TREATMENT OR PREVENTION DISORDERS ASSOCIATED WITH AN ABOVE-NORMAL NUMBER OF GRANULOCYTES IN A TISSUE Nestec S.A. (CH) 2018-10-10 EP claimed
US-20170312238-A1 METHODS OF MODULATION OF BRANCHED CHAIN ACIDS AND USES THEREOF ACER THERAPEUTICS INC. 2017-11-02 US claimed
US-9737499-B2 Methods of modulation of branched chain acids and uses thereof BAYLOR COLLEGE OF MEDICINE (US) 2017-08-22 US claimed
WO-2014001064-A1 CLAY-COMPATIBLE ADDITIVE FOR CONSTRUCTION CHEMICALS CONSTRUCTION RESEARCH & TECHNOLOGY GMBH (DE) 2014-01-03 WO claimed
US-20120220661-A1 METHODS OF MODULATION OF BRANCHED CHAIN ACIDS AND USES THEREOF BAYLOR COLLEGE OF MEDICINE (US) 2012-08-30 US claimed
EP-2456304-A1 METHODS OF MODULATION OF BRANCHED CHAIN ACIDS AND USES THEREOF Baylor College Of Medicine (US) 2012-05-30 EP claimed
US-20120065428-A1 METHOD FOR THE PREPARATION OF 2-KETO CARBOXYLIC ACID EVONIK DEGUSSA GMBH (DE) 2012-03-15 US claimed
WO-2011011781-A1 METHODS OF MODULATION OF BRANCHED CHAIN ACIDS AND USES THEREOF BAYLOR COLLEGE OF MEDICINE (US) 2011-01-27 WO claimed
CN-1643154-A Process for preparing chiral aromatic a-hydroxyketones using a 2-hydroxy-3-oxoacid synthase UNIV BEN GURION (IL) 2005-07-20 CN claimed
US-20020076393-A1 Method for stimulation of defensin production MAGAININ PHARMACEUTICALS, INC. 2002-06-20 US claimed
WO-2001068085-A1 A METHOD FOR STIMULATION OF DEFENSIN PRODUCTION GENAERA CORPORATION (US) 2001-09-20 WO claimed
EP-1093364-A1 A METHOD FOR STIMULATION OF DEFENSIN PRODUCTION BY EXPOSURE TO ISOLEUCIN MAGAININ PHARMACEUTICALS INC. (US) 2001-04-25 EP claimed
WO-1999059574-A1 A METHOD FOR STIMULATION OF DEFENSIN PRODUCTION BY EXPOSURE TO ISOLEUCIN MAGAININ PHARMACEUTICALS, INC. (US) 1999-11-25 WO claimed