Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 9/20 | 0.45 |
| ▸ | GSTA1 | P08263 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.45 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.45 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.45 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.45 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11603981 | 0.90 | MAPT (0.38) | GSTP1GSTA1ALDH1A1MAPTMEN1 | |
| SCHEMBL11604420 | 0.83 | GSTP1 (0.38) | GSTP1ALDH1A1MAPTTSHRPPARA | |
| SCHEMBL10833653 | 0.80 | TSHR (0.62) | GSTP1GSTA1ALDH1A1MAPTMEN1 | |
| SCHEMBL11455560 | 0.78 | SMN1; SMN2 (0.52) | ALDH1A1MAPTMEN1TP53TSHR | |
| SCHEMBL11603769 | 0.76 | THRB (0.52) | ALDH1A1MAPTLMNAHTTRECQL | |
| SCHEMBL11602279 | 0.76 | PTPN1 (0.35) | GSTP1HTTKMT2APPARAPPARG | |
| SCHEMBL11191192 | 0.74 | THRB (0.56) | GSTP1GSTA1ALDH1A1MAPTMEN1 | |
| SCHEMBL11194329 | 0.73 | MAOB (0.55) | MAPTKMT2ATHRATHRB | |
| SCHEMBL11200072 | 0.73 | THRA (0.42) | GSTP1GSTA1ALDH1A1MAPTMEN1 | |
| SCHEMBL1090803 | 0.73 | PPARG (0.55) | ALDH1A1LMNATSHRPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2830552-A1 | OPHTHALMIC DRUG DELIVERY DEVICE AND METHODS OF USE | Duke University (US) | 2015-02-04 | — | — | EP | disclosed |
| US-8642644-B2 | Ophthamological drugs | DUKE UNIVERSITY (US) | 2014-02-04 | — | — | US | disclosed |
| WO-2013148301-A1 | OPHTHALMIC DRUG DELIVERY DEVICE AND METHODS OF USE | DUKE UNIVERSITY (US) | 2013-10-03 | — | — | WO | disclosed |
| US-20090318542-A1 | OPHTHAMOLOGICAL DRUGS | DUKE UNIVERSITY | 2009-12-24 | — | — | US | disclosed |
| EP-1812017-A2 | OPHTHAMOLOGICAL DRUGS | Duke University (US) | 2007-08-01 | — | — | EP | disclosed |
| US-20060265776-A1 | Viability | DURHAM, UNIVERSITY OF (GB) | 2006-11-23 | — | — | US | disclosed |
| WO-2006047466-A2 | OPHTHAMOLOGICAL DRUGS | DUKE UNIVERSITY (US) | 2006-05-04 | — | — | WO | disclosed |
| EP-1608772-A1 | IMPROVEMENTS IN OR RELATING TO VIABILITY | UNIVERSITY OF DURHAM (GB) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004087944-A1 | IMPROVEMENTS IN OR RELATING TO VIABILITY | UNIVERSITY OF DURHAM (GB) | 2004-10-14 | — | — | WO | disclosed |
| US-5863948-A | Increasing aqueous humor outflow | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 1999-01-26 | — | — | US | disclosed |
| EP-0100053-B1 | COMPOUNDS HAVING ANGIOTENSIN CONVERTING ENZYME INHIBITORY ACTIVITY AND DIURETIC ACTIVITY | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1987-10-21 | — | — | EP | disclosed |
| US-4661515-A | N-CYCLOPENTYL GLYCINE DERIVATIVES | USV PHARMACEUTICAL CORPORATION (US) | 1987-04-28 | — | — | US | disclosed |
| US-4559332-A | 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof | CIBA GEIGY CORPORATION (US) | 1985-12-17 | — | — | US | disclosed |
| EP-0100053-A1 | Compounds having angiotensin converting enzyme inhibitory activity and diuretic activity | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1984-02-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318542-A1 | OPHTHAMOLOGICAL DRUGS | QDPR, PTGIR, PDE6C | GSTP1 939/4885GSTA1 1449/4885ALDH1A1 711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.