Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4409961 | 1.00 | ALDH1A1 (0.54) | ALDH1A1MAPTTSHRSMN1; SMN2NPC1 | |
| SCHEMBL65016 | 1.00 | ALDH1A1 (0.54) | ALDH1A1MAPTTSHRSMN1; SMN2NPC1 | |
| SCHEMBL64983 | 0.85 | HTT (0.50) | ALDH1A1TSHRSMN1; SMN2KMT2APOLB | |
| SCHEMBL1921934 | 0.84 | USP2 (0.58) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL14598813 | 0.84 | MAPT (0.50) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL24890805 | 0.83 | ALDH1A1 (0.51) | ALDH1A1MAPTTSHRSMN1; SMN2NPC1 | |
| SCHEMBL15630932 | 0.80 | ALDH1A1 (0.54) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL27812550 | 0.80 | ALDH1A1 (0.54) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL65696 | 0.79 | ALDH1A1 (0.71) | ALDH1A1MAPTTSHRSMN1; SMN2NPC1 | |
| SCHEMBL24890975 | 0.78 | HDAC1 (0.50) | ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318468-A1 | PYRAZOLE COMPOUNDS 436 | ASTRAZENECA AB (SE) | 2009-12-24 | — | — | US | disclosed |
| US-20090318468-A1 | PYRAZOLE COMPOUNDS 436 | ASTRAZENECA AB (SE) | 2009-12-24 | — | — | US | disclosed |
| US-20090318468-A1 | PYRAZOLE COMPOUNDS 436 | ASTRAZENECA AB (SE) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318468-A1 | PYRAZOLE COMPOUNDS 436 | CYP3A43, CYP3A7, CYP3A4 | ALDH1A1 283/4885MAPT 1028/4885TSHR 2321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.