Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.71 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.68 |
| ▸ | ACHE | P22303 | 3/20 | 0.60 |
| ▸ | SGMS1 | Q86VZ5 | 2/20 | 0.60 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.60 |
| ▸ | DPP4 | P27487 | 1/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9662554 | 1.00 | MAPT (0.71) | MAPTRXFP1LTB4RACHESGMS1 | |
| SCHEMBL31522354 | 1.00 | MAPT (0.71) | MAPTRXFP1LTB4RACHESGMS1 | |
| SCHEMBL1832377 | 1.00 | MAPT (0.71) | MAPTRXFP1LTB4RACHESGMS1 | |
| SCHEMBL2516030 | 1.00 | MAPT (0.71) | MAPTRXFP1LTB4RACHESGMS1 | |
| SCHEMBL9138858 | 1.00 | MAPT (0.71) | MAPTRXFP1LTB4RACHESGMS1 | |
| SCHEMBL503636 | 1.00 | MAPT (0.71) | MAPTRXFP1LTB4RACHESGMS1 | |
| SCHEMBL418561 | 0.98 | MAPT (0.68) | MAPTRXFP1LTB4RACHESGMS1 | |
| SCHEMBL28968198 | 0.96 | MAPT (0.66) | MAPTRXFP1LTB4RACHESGMS1 | |
| SCHEMBL284671 | 0.92 | SMN1; SMN2 (0.69) | MAPTRXFP1LTB4RDPP4SLC6A3 | |
| SCHEMBL3814880 | 0.92 | MAPT (0.83) | MAPTRXFP1LTB4RSLC6A3HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691845-A4 | COMPOUNDS CONTAINING MATRIX METALLOPROTEINASE SUBSTRATES AND METHODS OF THEIR USE | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1086160-B1 | CARBOXY-FUNCTIONALIZED POLYPHENYLENE ETHERS AND BLENDS CONTAINING THEM | GEN ELECTRIC (US) | 2006-10-04 | — | — | EP | disclosed |
| EP-1691845-A1 | COMPOUNDS CONTAINING MATRIX METALLOPROTEINASE SUBSTRATES AND METHODS OF THEIR USE | Bristol-Myers Squibb Pharma Company (US) | 2006-08-23 | — | — | EP | disclosed |
| US-20050106100-A1 | Compounds containing matrix metalloproteinase substrates and methods of their use | LANTHEUS MEDICAL IMAGING, INC. | 2005-05-19 | — | — | US | disclosed |
| WO-2005023314-A1 | COMPOUNDS CONTAINING MATRIX METALLOPROTEINASE SUBSTRATES AND METHODS OF THEIR USE | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-03-17 | — | — | WO | disclosed |
| US-6552133-B2 | Copolymerization or redistribution of o-hydroxyaromatic substituted aliphatic carboxylic acids into polyphenylene ethers; thermoplastic engineering resins with excellent hydrolytic stability, dimensional stability and toughness | GENERAL ELECTRIC COMPANY | 2003-04-22 | — | — | US | disclosed |
| EP-0895519-B1 | REDISTRIBUTION OF POLYPHENYLENE ETHERS AND POLYPHENYLENE ETHERS WITH NOVEL STRUCTURE | GEN ELECTRIC (US) | 2002-10-16 | — | — | EP | disclosed |
| US-20010034430-A1 | Carboxy-functionalized polyphenylene ethers and blends containing them | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2001-10-25 | — | — | US | disclosed |
| US-20010034418-A1 | Carboxy-functionalized polyphenylene ethers and blends containing them | YEAGER GARY WILLIAM (US) | 2001-10-25 | — | — | US | disclosed |
| US-6268463-B1 | POLYPHENYLENE ETHERS WITH CARBOXY GROUPS | GENERAL ELECTRIC COMPANY | 2001-07-31 | — | — | US | disclosed |
| EP-1086160-A1 | CARBOXY-FUNCTIONALIZED POLYPHENYLENE ETHERS AND BLENDS CONTAINING THEM | GENERAL ELECTRIC COMPANY (US) | 2001-03-28 | — | — | EP | disclosed |
| US-6063875-A | CONTAIN STRUCTURAL UNITS WITH A CARBOXYETHYL GROUP IN THE 2-POSITION; USEFUL AS COMPATIBILIZING COPOLYMERS WITH POLYMERS CONTAINING CARBOXYLIC ACID-REACTIVE GROUPS, SUCH AS POLYESTERS AND POLYAMIDES | GENERAL ELECTRIC COMPANY (US) | 2000-05-16 | — | — | US | disclosed |
| WO-1999064494-A1 | CARBOXY-FUNCTIONALIZED POLYPHENYLENE ETHERS AND BLENDS CONTAINING THEM | GENERAL ELECTRIC COMPANY (US) | 1999-12-16 | — | — | WO | disclosed |
| US-5880221-A | POLY(2,6-DIMETHYLPHENYL ETHER) REACTED WITH PHENOLIC COMPOUNDS | GENERAL ELECTRIC COMPANY (US) | 1999-03-09 | — | — | US | disclosed |
| EP-0895519-A1 | REDISTRIBUTION OF POLYPHENYLENE ETHERS AND POLYPHENYLENE ETHERS WITH NOVEL STRUCTURE | GENERAL ELECTRIC COMPANY (US) | 1999-02-10 | — | — | EP | disclosed |
| WO-1998036015-A1 | REDISTRIBUTION OF POLYPHENYLENE ETHERS AND POLYPHENYLENE ETHERS WITH NOVEL STRUCTURE | GENERAL ELECTRIC COMPANY (US) | 1998-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050106100-A1 | Compounds containing matrix metalloproteinase substrates and methods of their use | MMP1, MMP10, MMP8 | MAPT 2533/4885RXFP1 2548/4885LTB4R 1419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.