Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.32 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.32 |
| ▸ | WEE1 | P30291 | 2/20 | 0.32 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423212 | 0.86 | CNR2 (0.39) | METGSK3ARIPK2ACVR1MAPK8 | |
| SCHEMBL4413502 | 0.80 | CDK1 (0.36) | METALKGSK3ARIPK2ACVR1 | |
| SCHEMBL4414469 | 0.79 | JUN (0.33) | — | |
| SCHEMBL4420608 | 0.79 | CDK4 (0.44) | ALKEGFR | |
| SCHEMBL4413303 | 0.78 | MAPK8 (0.39) | METALKGSK3ARIPK2TBK1 | |
| SCHEMBL4416334 | 0.77 | IKBKB (0.42) | — | |
| SCHEMBL4413555 | 0.76 | BRAF (0.38) | TBK1WEE1MAPK8EGFRFGFR1 | |
| SCHEMBL4411476 | 0.76 | CDK1 (0.33) | METALKGSK3ARIPK2TBK1 | |
| SCHEMBL4412920 | 0.75 | MAPK10 (0.36) | TBK1WEE1EGFRFGFR1 | |
| SCHEMBL4414542 | 0.75 | KCNH3 (0.39) | TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615921-B1 | PYRIDO 2,3-D PYRIMIDIN-7-CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | EP | claimed |