Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 5/20 | 0.58 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.58 |
| ▸ | MPL | P40238 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.44 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL480651 | 0.86 | KMT2A (0.69) | TRPA1TRPV4MPLMAPTMEN1 | |
| SCHEMBL4418963 | 0.82 | GSTO1 (0.66) | TRPA1TRPV4MPLMAPTKMT2A | |
| SCHEMBL480617 | 0.82 | TRPA1 (0.59) | TRPA1TRPV4MPLMAPTMEN1 | |
| SCHEMBL4411028 | 0.81 | TRPA1 (0.60) | TRPA1TRPV4MPLMAPTMEN1 | |
| SCHEMBL13570207 | 0.80 | GSTO1 (0.50) | TRPA1TRPV4MEN1KMT2ALMNA | |
| SCHEMBL2478394 | 0.79 | TRPA1 (0.54) | TRPA1TRPV4MPLMAPTMEN1 | |
| SCHEMBL480598 | 0.77 | TRPA1 (0.61) | TRPA1TRPV4MPLMEN1KMT2A | |
| SCHEMBL480671 | 0.77 | TRPA1 (0.58) | TRPA1TRPV4MPLMEN1KMT2A | |
| SCHEMBL613256 | 0.77 | KMT2A (0.48) | TRPA1MEN1KMT2ARAB9AGSTO1 | |
| SCHEMBL609319 | 0.77 | TRPA1 (0.78) | TRPA1TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009144548-A1 | IMIDAZO [2,1-B] PURINE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2009-12-03 | — | — | WO | disclosed |