Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.60 |
| ▸ | CFTR | P13569 | 2/20 | 0.60 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.59 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.59 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.56 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.56 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | MPL | P40238 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13570207 | 0.88 | GSTO1 (0.50) | TRPA1CFTRTRPV3TRPV4MAPK1 | |
| SCHEMBL4418963 | 0.85 | GSTO1 (0.66) | TRPA1TRPV4SIRT5CSNK2A2CSNK2B | |
| SCHEMBL18724400 | 0.84 | ABL1 (0.69) | TRPA1CFTRTRPV3TRPV4SIRT5 | |
| SCHEMBL10288914 | 0.83 | MEN1 (0.65) | CSNK2A2CSNK2BCSNK2A1CSNK2A3MAPT | |
| SCHEMBL21586314 | 0.83 | ABL1 (0.70) | CFTRSIRT5MAPTMAPK1MEN1 | |
| SCHEMBL4410156 | 0.81 | FFAR4 (0.49) | TRPA1TRPV3TRPV4MEN1KMT2A | |
| SCHEMBL2452315 | 0.81 | ELOVL1 (0.72) | MAPTMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL4411635 | 0.81 | TRPA1 (0.58) | TRPA1TRPV4MAPTMPLMEN1 | |
| SCHEMBL480598 | 0.81 | TRPA1 (0.61) | TRPA1TRPV4MPLMEN1KMT2A | |
| SCHEMBL480671 | 0.81 | TRPA1 (0.58) | TRPA1TRPV4MPLMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009144548-A1 | IMIDAZO [2,1-B] PURINE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2009-12-03 | — | — | WO | disclosed |
| WO-2009144548-A1 | IMIDAZO [2,1-B] PURINE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2009-12-03 | — | — | WO | disclosed |