Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 3/20 | 0.69 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.69 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.62 |
| ▸ | EGFR | P00533 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4415185 | 0.86 | LMNA (0.58) | PIP4K2APIK3CGEGFRMAPTMEN1 | |
| SCHEMBL4412416 | 0.84 | ALDH1A1 (0.54) | PIP4K2APIK3CGABCG2EGFRMAPT | |
| SCHEMBL4416184 | 0.84 | LRRK2 (0.54) | PIP4K2APIK3CGABCG2MAPTMEN1 | |
| SCHEMBL4421383 | 0.83 | RAB9A (0.57) | PIP4K2APIK3CGABCG2EGFRMAPT | |
| SCHEMBL4427009 | 0.83 | AURKA (0.58) | ABCG2EGFRKDM4E | |
| SCHEMBL4414264 | 0.83 | MAPT (0.57) | EGFRMAPTMEN1KMT2AKDM4E | |
| SCHEMBL4415661 | 0.83 | EGFR (0.52) | PIP4K2APIK3CGABCG2EGFRMAPT | |
| SCHEMBL4416404 | 0.83 | ABCG2 (0.57) | PIP4K2APIK3CGABCG2EGFRMAPT | |
| SCHEMBL4414170 | 0.82 | ALDH1A1 (0.54) | PIP4K2APIK3CGMAPTMEN1KMT2A | |
| SCHEMBL4414043 | 0.82 | PIP4K2A (0.48) | PIP4K2APIK3CGABCG2EGFRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658290-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-04-15 | — | — | EP | claimed |
| CN-100439365-C | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2008-12-03 | — | — | CN | claimed |
| US-7338957-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2008-03-04 | — | — | US | claimed |
| JP-2007504159-A | — | — | 2007-03-01 | — | — | JP | claimed |
| CN-1842529-A | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2006-10-04 | — | — | CN | claimed |
| EP-1658290-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-24 | — | — | EP | claimed |
| WO-2005039486-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2005-05-06 | — | — | WO | claimed |
| EP-1658290-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-04-15 | — | — | EP | disclosed |
| CN-100439365-C | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2008-12-03 | — | — | CN | disclosed |
| US-20080108616-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-05-08 | — | — | US | disclosed |
| US-7338957-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2008-03-04 | — | — | US | disclosed |
| CN-1842529-A | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2006-10-04 | — | — | CN | disclosed |
| EP-1658290-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005039486-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108616-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | LCK, FYN, BMX | PIP4K2A 1032/4885PIK3CG 762/4885ABCG2 1387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.