Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4417954 | 0.88 | ALDH1A1 (0.42) | MEN1KMT2ASIGMAR1MAPTHTT | |
| SCHEMBL1333205 | 0.76 | CYP3A4 (0.52) | PARNCNOT7 | |
| SCHEMBL4419731 | 0.75 | TSHR (0.44) | MEN1KMT2AMAPTALDH1A1TDP1 | |
| SCHEMBL1334500 | 0.73 | PARN (0.41) | MEN1KMT2AMAPTHTTALDH1A1 | |
| SCHEMBL1334672 | 0.72 | ADORA1 (0.44) | MEN1KMT2AALDH1A1PARNCNOT7 | |
| SCHEMBL4416313 | 0.67 | CYP19A1 (0.37) | KMT2ASIGMAR1MAPTPKMRAB9A | |
| SCHEMBL11132823 | 0.65 | KCNH2 (0.57) | SIGMAR1MAPT | |
| SCHEMBL6266154 | 0.64 | MEN1 (0.56) | MEN1KMT2AMAPTHTTALDH1A1 | |
| SCHEMBL4414439 | 0.64 | POLB (0.37) | MEN1KMT2ASIGMAR1TDP1GAA | |
| SCHEMBL1333573 | 0.64 | CYP3A4 (0.52) | MAPTALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601649-A4 | A1 ADENOSINE RECEPTOR ANTAGONISTS | ENDACEA INC (US) | 2009-03-04 | — | — | EP | disclosed |
| EP-1601649-A2 | A1 ADENOSINE RECEPTOR ANTAGONISTS | Endacea Inc. (US) | 2005-12-07 | — | — | EP | disclosed |
| WO-2004074247-A2 | A1 ADENOSINE RECEPTOR ANTAGONISTS | ENDACEA, INC. (US) | 2004-09-02 | — | — | WO | disclosed |