Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 6/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4416340 | 0.88 | PLA2G7 (0.39) | PLA2G7KMT2AMAPT | |
| SCHEMBL4414439 | 0.83 | POLB (0.37) | CYP19A1SIGMAR1KMT2ACYP3A4KCNJ1 | |
| SCHEMBL4416381 | 0.70 | GAA (0.39) | KMT2ACYP3A4MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL5567623 | 0.68 | MEN1 (0.31) | KMT2AMAPT | |
| SCHEMBL4412642 | 0.67 | MEN1 (0.41) | SIGMAR1KMT2AMAPTRAB9APKM | |
| SCHEMBL177815 | 0.67 | POLB (0.67) | CYP19A1CYP11B1CYP11B2KMT2AMAPT | |
| SCHEMBL11770983 | 0.62 | KCNJ1 (0.48) | SIGMAR1KMT2ACYP3A4MAPTKCNJ1 | |
| SCHEMBL1163856 | 0.62 | SIGMAR1 (0.65) | SIGMAR1KMT2AMAPTRAB9AKCNJ1 | |
| SCHEMBL1163877 | 0.62 | SIGMAR1 (0.65) | SIGMAR1KMT2AMAPTRAB9AKCNJ1 | |
| SCHEMBL3232073 | 0.61 | MMP2 (0.48) | PLA2G7KMT2AMAPTRAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601649-A4 | A1 ADENOSINE RECEPTOR ANTAGONISTS | ENDACEA INC (US) | 2009-03-04 | — | — | EP | disclosed |
| EP-1601649-A2 | A1 ADENOSINE RECEPTOR ANTAGONISTS | Endacea Inc. (US) | 2005-12-07 | — | — | EP | disclosed |
| WO-2004074247-A2 | A1 ADENOSINE RECEPTOR ANTAGONISTS | ENDACEA, INC. (US) | 2004-09-02 | — | — | WO | disclosed |