Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | PCK1 | P35558 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TPH1 | P17752 | 4/20 | 0.46 |
| ▸ | TPH2 | Q8IWU9 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.43 |
| ▸ | G6PD | P11413 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3981826 | 0.77 | PCK1 (0.78) | PCK1 | |
| SCHEMBL6265951 | 0.77 | TPH1 (0.60) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6390495 | 0.73 | PCK1 (0.51) | MEN1KMT2AALDH1A1PCK1TPH1 | |
| SCHEMBL6383665 | 0.72 | PCK1 (0.49) | MEN1KMT2AALDH1A1PCK1TPH1 | |
| SCHEMBL6390388 | 0.72 | PCK1 (0.51) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4616197 | 0.68 | PCK1 (0.38) | MEN1KMT2ATDP1ALDH1A1KDM4E | |
| SCHEMBL3981808 | 0.67 | SLC22A2 (0.42) | MEN1KMT2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL4613028 | 0.67 | KMT2A (0.41) | MEN1KMT2ATDP1ALDH1A1KDM4E | |
| SCHEMBL22800969 | 0.65 | ALDH1A1 (1.00) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4412642 | 0.64 | MEN1 (0.41) | MEN1KMT2ATDP1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599477-A1 | SULFONAMIDE SUBSTITUTED XANTHINE DERIVATIVES FOR USE AS PEPCK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-30 | — | — | EP | disclosed |
| EP-1515972-A1 | AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2005-03-23 | — | — | EP | disclosed |
| WO-2004074288-A1 | SULFONAMIDE SUBSTITUTED XANTHINE DERIVATIVES FOR USE AS PEPCK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-02 | — | — | WO | disclosed |
| WO-2003106459-A1 | AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2003-12-24 | — | — | WO | disclosed |