SCHEMBL4412797

SCHEMBL4412797

CC(C)(C)OC(=O)N1CCC(OCc2noc(-c3ccc(C(N)=O)cc3)n2)CC1

nearest known ligand 0.57

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 12/20 0.57
CHEK2 O96017 3/20 0.49
HDAC4 P56524 3/20 0.47
HDAC6 Q9UBN7 1/20 0.43
CETP P11597 1/20 0.43
SPHK2 Q9NRA0 1/20 0.42
SPHK1 Q9NYA1 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4415562 0.92 GPR119 (0.58) GPR119CHEK2HDAC4HDAC6CETP
SCHEMBL4415700 0.92 GPR119 (0.58) GPR119HDAC4HDAC6CETP
SCHEMBL13602338 0.91 GPR119 (0.56) GPR119CHEK2HDAC4HDAC6CETP
SCHEMBL4414106 0.90 GPR119 (0.56) GPR119HDAC4HDAC6CETP
SCHEMBL12548315 0.90 GPR119 (0.57) GPR119HDAC4CETP
SCHEMBL4419139 0.89 GPR119 (0.54) GPR119CHEK2HDAC4HDAC6CETP
SCHEMBL13598291 0.89 GPR119 (0.55) GPR119HDAC4CETPSPHK2SPHK1
SCHEMBL4415808 0.89 GPR119 (0.59) GPR119
SCHEMBL4412788 0.89 GPR119 (0.55) GPR119HDAC4HDAC6CETP
SCHEMBL4418527 0.89 GPR119 (0.58) GPR119CETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090325924-A1 GPCR Agonists PROSIDION LIMITED (GB) 2009-12-31 US disclosed
US-20090325924-A1 GPCR Agonists PROSIDION LIMITED (GB) 2009-12-31 US disclosed
US-20090325924-A1 GPCR Agonists PROSIDION LIMITED (GB) 2009-12-31 US disclosed
WO-2007003960-A1 GPCR AGONISTS PROSIDION LIMITED (GB) 2007-01-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090325924-A1 GPCR Agonists GPR119, GCGR, GPR27 GPR119 1/4885CHEK2 3701/4885HDAC4 2550/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.