SCHEMBL4415700

SCHEMBL4415700

CC(C)(C)OC(=O)N1CCC(OCc2noc(-c3ccc(C(=O)O)cc3)n2)CC1

nearest known ligand 0.58

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 13/20 0.58
HDAC4 P56524 3/20 0.45
CETP P11597 2/20 0.43
NR1H4 Q96RI1 1/20 0.43
KMT2A Q03164 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4415562 0.93 GPR119 (0.58) GPR119HDAC4CETPHDAC6
SCHEMBL4412797 0.92 GPR119 (0.57) GPR119HDAC4CETPHDAC6
SCHEMBL4418527 0.91 GPR119 (0.58) GPR119CETP
SCHEMBL4414106 0.91 GPR119 (0.56) GPR119HDAC4CETPHDAC6
SCHEMBL12548315 0.90 GPR119 (0.57) GPR119HDAC4CETPKMT2A
SCHEMBL13598291 0.90 GPR119 (0.55) GPR119HDAC4CETPKMT2A
SCHEMBL4412788 0.90 GPR119 (0.55) GPR119HDAC4CETPKMT2AHDAC6
SCHEMBL4415808 0.90 GPR119 (0.59) GPR119
SCHEMBL13602338 0.90 GPR119 (0.56) GPR119HDAC4CETPHDAC6
SCHEMBL387006 0.89 GPR119 (0.70) GPR119HDAC4CETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090325924-A1 GPCR Agonists PROSIDION LIMITED (GB) 2009-12-31 US disclosed
EP-1907383-A1 GPCR AGONISTS Prosidion Limited (GB) 2008-04-09 EP disclosed
WO-2007003960-A1 GPCR AGONISTS PROSIDION LIMITED (GB) 2007-01-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090325924-A1 GPCR Agonists GPR119, GCGR, GPR27 GPR119 1/4885HDAC4 2550/4885CETP 1002/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.