Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.33 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | APEX1 | P27695 | 2/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5315766 | 0.68 | KMT2A (0.42) | TSHRHTTALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL466078 | 0.67 | TSHR (0.38) | TSHRHTTLMNAALDH1A1CHRM2 | |
| SCHEMBL11760214 | 0.67 | TSHR (0.59) | TSHRHTTLMNAALDH1A1CHRM2 | |
| SCHEMBL4372909 | 0.67 | TSHR (0.51) | TSHRHTTLMNAALDH1A1CHRM2 | |
| SCHEMBL28210831 | 0.67 | TSHR (0.51) | TSHRHTTLMNAALDH1A1CHRM2 | |
| Hydrochloric Acid SCHEMBL868011 | 0.66 | TSHR (0.41) | TSHRHTTLMNAALDH1A1CHRM2 | |
| SCHEMBL3103825 | 0.66 | TSHR (0.39) | TSHRHTTLMNAALDH1A1CHRM2 | |
| SCHEMBL898823 | 0.66 | TSHR (0.39) | TSHRHTTLMNAALDH1A1KMT2A | |
| Ethylene SCHEMBL28313751 | 0.66 | TSHR (0.50) | TSHRHTTLMNAALDH1A1CHRM2 | |
| SCHEMBL28167209 | 0.66 | TSHR (0.50) | TSHRHTTLMNAALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814511-B1 | METHOD FOR THE PERMANENT SHAPING OF HAIR USING A CATIONIC CELLULOSE DERIVATIVE | PROCTER & GAMBLE (US) | 2009-12-23 | — | — | EP | claimed |
| EP-0559851-B1 | HAIR-SETTING AGENT AND A HAIR-PERMING METHOD USING THIS AGENT | WELLA AG (DE) | 1995-08-23 | — | — | EP | claimed |