Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | TPO | P07202 | 1/20 | 0.38 |
| ▸ | EPX | P11678 | 1/20 | 0.38 |
| ▸ | LPO | P22079 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11428548 | 0.71 | HTR2A (0.50) | MEN1NPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL4412993 | 0.70 | EGFR (0.55) | EGFRFGFR4ALDH1A1HTTMAP4K4 | |
| SCHEMBL4417418 | 0.69 | EGFR (0.61) | EGFRFGFR4HTTKCNH2 | |
| SCHEMBL29985188 | 0.68 | EGFR (0.60) | EGFRFGFR4ALDH1A1 | |
| SCHEMBL1771615 | 0.68 | EGFR (0.60) | EGFRALDH1A1 | |
| SCHEMBL11420788 | 0.68 | HTR2A (0.50) | MEN1ALDH1A1HPGDRAB9AKMT2A | |
| SCHEMBL1771905 | 0.68 | EGFR (0.60) | EGFRFGFR4ALDH1A1 | |
| SCHEMBL15340900 | 0.67 | TEAD4 (0.48) | MEN1NPC1ALDH1A1HPGDKMT2A | |
| SCHEMBL241727 | 0.67 | EGFR (0.58) | EGFRFGFR4ALDH1A1PDGFRBPDGFRA | |
| SCHEMBL28801910 | 0.67 | EGFR (0.58) | EGFRFGFR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE41065-E1 | Alkynl and azido-substituted 4-anilinoquinazolines | PFIZER, INC. (US) | 2009-12-29 | — | — | US | disclosed |