Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Dimethylcarbate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 10/20 | 0.69 |
| ▸ | BCHE | P06276 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylcarbate SCHEMBL4413044 | 0.85 | ACHE (0.67) | ACHEBCHELMNAMEN1KMT2A | |
| SCHEMBL1920707 | 0.83 | ACHE (1.00) | ACHEBCHELMNATSHROPRM1 | |
| Water SCHEMBL11727004 | 0.81 | ACHE (0.95) | ACHEBCHELMNATSHROPRM1 | |
| Iodide SCHEMBL29488102 | 0.81 | ACHE (0.95) | ACHEBCHELMNATSHROPRM1 | |
| Hydrochloric Acid SCHEMBL28469713 | 0.81 | ACHE (0.95) | ACHEBCHELMNATSHROPRM1 | |
| Hydrochloric Acid SCHEMBL30945416 | 0.81 | ACHE (0.95) | ACHEBCHELMNATSHROPRM1 | |
| Dimethylcarbate SCHEMBL131467 | 0.76 | ACHE (0.63) | ACHEBCHELMNAMEN1KMT2A | |
| Phenol SCHEMBL27915437 | 0.72 | CA12 (0.58) | ACHEBCHELMNAMEN1KMT2A | |
| SCHEMBL13822433 | 0.68 | ACHE (0.52) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL8026154 | 0.68 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4230202-A1 | BOWEL CARE USING IONTOPHORESIS | The United States Government Represented by the Department of Veterans Affairs (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-3413888-B1 | BOWEL CARE USING IONTOPHORESIS | US GOV VETERANS AFFAIRS (US) | 2023-05-10 | — | — | EP | disclosed |
| US-20190029989-A1 | BOWEL CARE USING IONTOPHORESIS | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2019-01-31 | — | — | US | disclosed |
| EP-3413888-A2 | BOWEL CARE USING IONTOPHORESIS | United States Government as Represented by The Department of Veterans Affairs (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139794-A2 | BOWEL CARE USING IONTOPHORESIS | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (US) | 2017-08-17 | — | — | WO | disclosed |
| US-7635709-B2 | Synergistic mixture of acetylcholinesterase inhibitor and anticholinergic agent; side effect reduction | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (US) | 2009-12-22 | — | — | US | disclosed |
| US-20040082644-A1 | Compositions and methods for bowel care in individuals with chronic intestinal pseudo-obstruction | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, DBA, THE DEPARTMENT OF VETERANS AFFAIRS | 2004-04-29 | — | — | US | disclosed |