Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Neostigmine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 13/20 | 1.00 |
| ▸ | BCHE | P06276 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.97 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.97 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Neostigmine SCHEMBL29603805 | 1.00 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL34419 | 1.00 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL29618009 | 0.98 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL30029632 | 0.98 | ACHE (0.97) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL20425365 | 0.98 | ACHE (0.97) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL41128 | 0.98 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL16228482 | 0.98 | ACHE (0.97) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL7576189 | 0.97 | ACHE (0.94) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL7633009 | 0.94 | ACHE (0.88) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL2028206 | 0.93 | ACHE (0.89) | ACHEBCHELMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675838-A1 | LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS | Puretecch LYT, Inc. (US) | 2020-07-08 | — | — | EP | disclosed |
| WO-2019046491-A1 | LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS | ARIYA THERAPEUTICS, INC. (US) | 2019-03-07 | — | — | WO | disclosed |
| EP-0941224-A4 | MULTIVALENT SALTS OF PYRIDOSTIGMINE AND RELATED COMPOUNDS | ICN PHARMACEUTICALS (US) | 2000-01-12 | — | — | EP | disclosed |
| EP-0941224-A1 | MULTIVALENT SALTS OF PYRIDOSTIGMINE AND RELATED COMPOUNDS | ICN Pharmaceuticals, Inc. (US) | 1999-09-15 | — | — | EP | disclosed |
| WO-1998022458-A1 | MULTIVALENT SALTS OF PYRIDOSTIGMINE AND RELATED COMPOUNDS | ICN PHARMACEUTICALS, INC. (US) | 1998-05-28 | — | — | WO | disclosed |