Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 2/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.46 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3801397 | 0.98 | LDHA (0.53) | LDHAPPARAHTTMMP1MMP13 | |
| SCHEMBL28246723 | 0.96 | LDHA (0.51) | LDHAPPARAHTTMMP1MMP13 | |
| SCHEMBL20269317 | 0.84 | SMN1; SMN2 (0.49) | LDHAHTTMMP1MMP13NPC1 | |
| SCHEMBL28136422 | 0.84 | LDHA (0.53) | LDHAPPARAHTTMMP1MMP13 | |
| SCHEMBL13903099 | 0.82 | PTPRB (0.54) | LDHAHTTMMP1MMP13NPC1 | |
| SCHEMBL7676911 | 0.82 | LDHA (0.51) | LDHAPPARAHTTMMP1MMP13 | |
| SCHEMBL3739737 | 0.82 | LDHA (0.51) | LDHAPPARAHTTMMP1MMP13 | |
| SCHEMBL5208103 | 0.81 | LDHA (0.55) | LDHAHTTNPC1RAB9APOLB | |
| SCHEMBL1424653 | 0.81 | BLM (0.67) | LDHAPPARAHTTMMP1MMP13 | |
| SCHEMBL2033365 | 0.81 | BLM (0.67) | LDHAPPARAHTTMMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120898-A1 | CALCILYTIC COMPOUNDS | SmithKline Beecham Corporation (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008077009-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-26 | — | — | WO | disclosed |