SCHEMBL44137

SCHEMBL44137

CC(O)C(O)C(N1C(=O)C=CC1=O)N1C(=O)C=CC1=O

nearest known ligand 0.35

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 4/20 0.35
GSK3A P49840 1/20 0.35
GSK3B P49841 1/20 0.35
GMNN O75496 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
MAPT P10636 1/20 0.31
THPO P40225 1/20 0.31
BLM P54132 1/20 0.31
PMP22 Q01453 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
FAAH O00519 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17924892 0.76 MGLL (0.38) MGLLGSK3AGSK3BGMNNALDH1A1
SCHEMBL331187 0.75 MGLL (0.41) MGLLGSK3AGSK3BGMNNALDH1A1
SCHEMBL13742892 0.75 MGLL (0.41) MGLLGSK3AGSK3BGMNNALDH1A1
SCHEMBL11457779 0.74 MGLL (0.42) MGLLGSK3AGSK3BGMNNALDH1A1
SCHEMBL17924891 0.73 MGLL (0.35) MGLLGSK3AGSK3BGMNNALDH1A1
SCHEMBL17924834 0.73 MGLL (0.35) MGLLGSK3AGSK3BGMNNALDH1A1
SCHEMBL17924943 0.73 MGLL (0.35) MGLLGSK3AGSK3BGMNNALDH1A1
SCHEMBL31071892 0.71 MGLL (0.35) MGLLGSK3AGSK3BGMNNALDH1A1
SCHEMBL17924921 0.70 MGLL (0.38) MGLLGSK3AGSK3BGMNNALDH1A1
SCHEMBL708908 0.69 MGLL (0.38) MGLLGSK3AGSK3BGMNNALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 656 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240011011-A1 BIOCATALYTICAL COMPOSITION INOFEA GMBH (CH) 2024-01-11 US claimed
US-10953073-B2 XTEN conjugate compositions and methods of making same AMUNIX PHARMACEUTICALS, INC. (US) 2021-03-23 US claimed
EP-2494075-B1 TEMPLATED NANOCONJUGATES UNIV NORTHWESTERN (US) 2018-04-04 EP claimed
US-20160168559-A1 BIOCATALYTICAL COMPOSITION INOFEA GMBH (CH) 2016-06-16 US claimed
EP-3027750-A1 BIOCATALYTICAL COMPOSITION Inofea GmbH (CH) 2016-06-08 EP claimed
WO-2015014888-A1 BIOCATALYTICAL COMPOSITION INOFEA GMBH (CH) 2015-02-05 WO claimed
EP-2675481-A1 CYTOTOXIC BENZODIAZEPINE DERIVATIVES AND METHODS OF PREPARATION ImmunoGen, Inc. (US) 2013-12-25 EP claimed
EP-2650309-A9 CONJUGATE OF FOLATE AND ANTIBODY, PREPARATION METHOD AND USE THEREOF Wuhan Huayao Biopharmaceutical Co., Ltd (CN) 2013-12-11 EP claimed
EP-2650309-A1 CONJUGATE OF FOLATE AND ANTIBODY, PREPARATION METHOD AND USE THEREOF Wuhan Huayao Biopharmaceutical Co., Ltd (CN) 2013-10-16 EP claimed
US-20130259882-A1 Conjugate of Folate and Antibody Preparation Method and Use Thereof ZHEJIANG JIANFENG HANSHENG BIOSCIENCES CO., LTD. (CN) 2013-10-03 US claimed
EP-2494075-A2 TEMPLATED NANOCONJUGATES Northwestern University (US) 2012-09-05 EP claimed
WO-2012112708-A1 CYTOTOXIC BENZODIAZEPINE DERIVATIVES AND METHODS OF PREPARATION IMMUNOGEN, INC. (US) 2012-08-23 WO claimed
WO-2012020230-A1 POLYMER PARTICLE DNA TRACER TECHNOLOGIES LIMITED (GB) 2012-02-16 WO claimed
WO-2011053940-A2 TEMPLATED NANOCONJUGATES NORTHWESTERN UNIVERSITY (US) 2011-05-05 WO claimed
WO-2010063725-A2 STRUCTURING PARTICLES INTO USEFUL STRUCTURES AND THEIR USE IN LIFE SCIENCE MATTIASSON BO (SE) 2010-06-10 WO claimed
WO-2009077438-A1 METHOD FOR PREPARING PROTEIN CONJUGATES GLAXOSMITHKLINE BIOLOGICALS S.A. (BE) 2009-06-25 WO claimed
US-20090098574-A1 FUNCTIONALIZATION OF GOLD NANOPARTICLES WITH ORIENTED PROTEINS, APPLICATION TO THE HIGH-DENSITY LABELLING OF CELL MEMBRANES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) 2009-04-16 US claimed
EP-2018559-A1 FUNCTIONALIZATION OF GOLD NANOPARTICLES WITH ORIENTED PROTEINS. APPLICATION TO THE HIGH-DENSITY LABELLING OF CELL MEMBRANES Centre National de la Recherche Scientifique (CNRS) (FR) 2009-01-28 EP claimed
WO-2007122259-A1 FUNCTIONALIZATION OF GOLD NANOPARTICLES WITH ORIENTED PROTEINS. APPLICATION TO THE HIGH-DENSITY LABELLING OF CELL MEMBRANES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2007-11-01 WO claimed
US-20030152932-A1 Detection method using dissociated rolling circle amplification QIAGEN GMBH (DE) 2003-08-14 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10953073-B2 XTEN conjugate compositions and methods of making same XPA, TXLNA, NGLY1 MGLL 3726/4885GSK3A 3808/4885GSK3B 4105/4885
US-20130259882-A1 Conjugate of Folate and Antibody Preparation Method and Use Thereof FOLR1, FOLR2, DHFR MGLL 4810/4885GSK3A 4870/4885GSK3B 4878/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.